Prevalence of chronic endometritis in infertile women undergoing hysteroscopy and its association with intrauterine abnormalities: A Cross-Sectional study.

IF 1.8 Q3 OBSTETRICS & GYNECOLOGY Jornal Brasileiro de Reproducao Assistida Pub Date : 2024-08-26 DOI:10.5935/1518-0557.20240011
Sedigheh Hosseini, Hajar Abbasi, Saghar Salehpour, Nasrin Saharkhiz, Mitra Nemati
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Abstract

Objective: Chronic endometritis (CE) is an inflammatory condition with several different risk factors. We aimed to examine whether intrauterine abnormalities, such as endometrial polyps, submucosal myomas, intrauterine adhesions, or a septate uterus, were associated with an increased likelihood of developing chronic endometritis.

Methods: A cross-sectional study was conducted on 335 infertile women who underwent hysteroscopy surgery at the Ayatollah Taleghani Hospital Infertility Center, affiliated by Shahid Beheshti University of Medical Sciences, in 2022. All participants in the study underwent hysteroscopic surgery, which allowed for direct visualization of the intrauterine cavity, and endometrial biopsies were taken for further analysis. To characterize endometritis, plasma cell infiltration was assessed. Patients with ≥5 plasma cells observed in 10 high-power fields were defined as having chronic endometritis.

Results: Endometritis was observed in 51.3% of the patients, totaling 172 individuals. Logistic regression analysis revealed that patients with endometrial polyps had 5.2 times higher odds of developing endometritis compared to patients without polyps (95% CI = 2.9, 9.2) (p-value <0.001). Similarly, patients with intrauterine adhesions had a significant increase in the odds of endometritis (OR = 4.6, 95% CI = 2.1, 10.1) (p-value <0.001).

Conclusions: Treatment or removal of endometrial abnormalities through hysteroscopic procedures may help to reduce the risk of chronic endometritis and improve fertility outcomes. Further research is necessary.

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接受宫腔镜检查的不孕妇女中慢性子宫内膜炎的发病率及其与宫内畸形的关系:一项横断面研究。
目的:慢性子宫内膜炎(CE)是一种炎症,有多种不同的风险因素。我们旨在研究子宫内异常(如子宫内膜息肉、粘膜下肌瘤、宫腔粘连或子宫中隔)是否与患慢性子宫内膜炎的可能性增加有关:这项横断面研究针对2022年在沙希德-贝赫什提医科大学附属阿亚图拉-塔勒加尼医院不孕不育中心接受宫腔镜手术的335名不孕妇女。这项研究的所有参与者都接受了宫腔镜手术,该手术可直接观察宫腔内的情况,并采集子宫内膜活检样本进行进一步分析。为确定子宫内膜炎的特征,对浆细胞浸润进行了评估。在 10 个高倍视野中观察到≥5 个浆细胞的患者被定义为慢性子宫内膜炎:结果:51.3%的患者(共 172 人)患有子宫内膜炎。逻辑回归分析显示,与没有息肉的患者相比,有子宫内膜息肉的患者患子宫内膜炎的几率高出 5.2 倍(95% CI = 2.9,9.2)(P 值 结论:治疗或切除子宫内膜异常的方法可能会导致子宫内膜炎的发生:通过宫腔镜手术治疗或切除子宫内膜异常可能有助于降低慢性子宫内膜炎的风险并改善生育结果。有必要开展进一步研究。
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来源期刊
CiteScore
3.30
自引率
6.70%
发文量
56
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