Prenatal maternal immune activation predicts observed fearfulness in infancy.

IF 3.1 2区心理学 Q2 PSYCHOLOGY, DEVELOPMENTAL Developmental Psychology Pub Date : 2024-11-01 Epub Date: 2024-03-28 DOI:10.1037/dev0001718

Jishyra Serrano, Sean Womack, Catherine Yount, Sadia Firoza Chowdhury, Molly Arnold, Jessica Brunner, Zoe Duberstein, Emily S Barrett, Kristin Scheible, Richard K Miller, Thomas G O'Connor

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Abstract

Fear reactivity is an early emerging temperament trait that predicts longer term behavioral and health outcomes. The current analysis tests the hypothesis, an extension of prior research on maternal immune activation (MIA), that the prenatal maternal immune system is a reliable predictor of observed fear reactivity in infancy. The analysis is based on a prospective longitudinal cohort study that collected data from the first trimester and conducted observational assessments of temperament at approximately 12 months of age (n = 281 infants). MIA was assessed from immune biomarkers measured in maternal blood at each trimester; infant temperament was assessed using the Laboratory Temperament Assessment Battery assessment at 12 months; covariates included family and sociodemographic factors. Patterns of inflammatory markers across gestation reliably predicted observed temperament: elevated prenatal MIA was associated with high fear reactivity to novel stimuli. The findings provide novel evidence of prenatal origins of fear reactivity and suggest developmental mechanisms that may underlie early emerging individual differences in child temperament. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

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产前母体免疫激活可预测婴儿期的恐惧感。

恐惧反应性是一种早期出现的气质特征，可预测较长期的行为和健康结果。目前的分析测试了一个假设，即产前母体免疫系统是婴儿期所观察到的恐惧反应性的可靠预测因素，该假设是对先前有关母体免疫激活（MIA）研究的延伸。这项分析基于一项前瞻性纵向队列研究，该研究从婴儿出生后的头三个月开始收集数据，并在婴儿约 12 个月大时对其性情进行观察评估（n = 281 名婴儿）。根据每个孕期在母体血液中测量的免疫生物标志物评估了 MIA；在婴儿 12 个月时使用实验室气质评估电池评估了婴儿的气质；协变量包括家庭和社会人口因素。整个妊娠期的炎症标志物模式可靠地预测了观察到的气质：产前 MIA 升高与对新刺激的高恐惧反应相关。这些发现提供了产前恐惧反应性起源的新证据，并提出了可能是儿童气质早期个体差异的发展机制。(PsycInfo Database Record (c) 2024 APA，保留所有权利）。

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来源期刊

Developmental Psychology PSYCHOLOGY, DEVELOPMENTAL-

CiteScore

5.80

自引率

2.50%

发文量

329

期刊介绍： Developmental Psychology ® publishes articles that significantly advance knowledge and theory about development across the life span. The journal focuses on seminal empirical contributions. The journal occasionally publishes exceptionally strong scholarly reviews and theoretical or methodological articles. Studies of any aspect of psychological development are appropriate, as are studies of the biological, social, and cultural factors that affect development. The journal welcomes not only laboratory-based experimental studies but studies employing other rigorous methodologies, such as ethnographies, field research, and secondary analyses of large data sets. We especially seek submissions in new areas of inquiry and submissions that will address contradictory findings or controversies in the field as well as the generalizability of extant findings in new populations. Although most articles in this journal address human development, studies of other species are appropriate if they have important implications for human development. Submissions can consist of single manuscripts, proposed sections, or short reports.