{"title":"Biochemical features of glycolysis in cancer cells with different metastatic potential","authors":"Solomia Hnatiuk, Denys Kolesnyk, Galina Solyanik","doi":"10.1063/10.0024974","DOIUrl":null,"url":null,"abstract":"It is known that, compared with normal cells, cancer cells are characterized by an intensification of glycolysis and an increase in glucose uptake to ensure high proliferative activity. Meanwhile, the question of the relationship between the intensity of glycolysis and the metastatic potential of tumor cells remains open. The aim of the study was to determine the rate of glucose uptake (GCR) and lactate production (LPR) by Lewis lung carcinoma cells with high (LLC) and low metastatic potential (LLC/R9) during 1-day growth in vitro under standard incubation conditions. The results showed that glycolysis intensity was significantly higher in low-metastatic Lewis lung carcinoma cells compared to the high-metastatic cells.","PeriodicalId":0,"journal":{"name":"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"","FirstCategoryId":"101","ListUrlMain":"https://doi.org/10.1063/10.0024974","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
It is known that, compared with normal cells, cancer cells are characterized by an intensification of glycolysis and an increase in glucose uptake to ensure high proliferative activity. Meanwhile, the question of the relationship between the intensity of glycolysis and the metastatic potential of tumor cells remains open. The aim of the study was to determine the rate of glucose uptake (GCR) and lactate production (LPR) by Lewis lung carcinoma cells with high (LLC) and low metastatic potential (LLC/R9) during 1-day growth in vitro under standard incubation conditions. The results showed that glycolysis intensity was significantly higher in low-metastatic Lewis lung carcinoma cells compared to the high-metastatic cells.
分享
京公网安备 11010802042870号
京ICP备2023020795号-1
求助内容：
应助结果提醒方式：
扫码关注我们
