Effect of the Solvent Nature on the Biological Activity of Gold-Containing Systems

IF 1.1 4区 化学 Q4 CHEMISTRY, PHYSICAL Doklady Physical Chemistry Pub Date : 2024-03-28 DOI:10.1134/S0012501624600025
A. A. Voronova, A. V. Naumkin, A. Yu. Pereyaslavtsev, T. Batsalova, B. Dzhambazov, A. Yu. Vasil’kov
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Abstract

Gold nanoparticles were prepared by metal vapor synthesis using isopropyl alcohol, acetone, and toluene as dispersion media. The electronic states of the metal and the nature of the adsorbed layer on the nanoparticle surface were investigated. Analysis of the photoelectron spectra of the obtained nanoparticles showed that regardless of the synthesis conditions, gold occurs in the Au0, Au+, and Au3+ states in all samples, and a carbon-containing shell is present on all types of metal particles. A study of the anticancer activity of nanoparticles in vitro using human cell lines revealed a dependence of the biological activity on the exposure time for samples obtained in a toluene dispersion medium. The metabolic activity of cancer cells treated with gold nanoparticles formed in isopropyl alcohol or acetone dropped in the very beginning of testing.

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溶剂性质对含金体系生物活性的影响
摘要 以异丙醇、丙酮和甲苯为分散介质,采用金属蒸气合成法制备了金纳米粒子。研究了金属的电子状态和纳米粒子表面吸附层的性质。对所获纳米粒子的光电子能谱分析表明,无论合成条件如何,所有样品中的金都处于 Au0、Au+ 和 Au3+ 态,所有类型的金属颗粒上都有含碳的外壳。利用人体细胞系对纳米颗粒的体外抗癌活性进行的研究表明,在甲苯分散介质中获得的样品的生物活性与暴露时间有关。用异丙醇或丙酮中形成的金纳米粒子处理的癌细胞的新陈代谢活性在测试开始时就下降了。
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来源期刊
Doklady Physical Chemistry
Doklady Physical Chemistry 化学-物理化学
CiteScore
1.50
自引率
0.00%
发文量
9
审稿时长
6-12 weeks
期刊介绍: Doklady Physical Chemistry is a monthly journal containing English translations of current Russian research in physical chemistry from the Physical Chemistry sections of the Doklady Akademii Nauk (Proceedings of the Russian Academy of Sciences). The journal publishes the most significant new research in physical chemistry being done in Russia, thus ensuring its scientific priority. Doklady Physical Chemistry presents short preliminary accounts of the application of the state-of-the-art physical chemistry ideas and methods to the study of organic and inorganic compounds and macromolecules; polymeric, inorganic and composite materials as well as corresponding processes. The journal is intended for scientists in all fields of chemistry and in interdisciplinary sciences.
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