Enhancing Diagnostic Precision with Utilizing Combined CRP and IL-6 Testing for Deep Vein Thrombosis Detection Post-Endometrial Cancer Surgery.

IF 1.9 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Alternative therapies in health and medicine Pub Date : 2025-01-01

Lisha Wang, Li Liu, Yulan Geng, Huan Ren, Tongfang Liu, Jiajia Liu

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Abstract

Background: Deep vein thrombosis is a common complication after surgery, particularly in cancer patients, ‎necessitating efficient diagnostic methods for timely intervention.

Objective: This study aimed to investigate the potential of combining C-reactive protein (CRP) and interleukin-6 (IL-6) tests in diagnosing deep vein thrombosis (DVT) following endometrial cancer surgery.

Methods: A cohort of 60 patients who developed DVT post-endometrial cancer surgery and were admitted to the First Hospital of Hebei Medical University between March 2018 and March 2022 constituted the DVT group. Additionally, 60 patients who underwent endometrial cancer surgery during the same period but did not develop DVT formed the non-DVT group. Serum levels of CRP and IL-6 were quantified and compared between the two groups using reliable laboratory techniques. Subsequently, the diagnostic accuracy of single-parameter testing (CRP or IL-6 alone) versus combined testing (CRP and IL-6) for postoperative DVT was assessed.

Results: Analysis revealed significantly elevated levels of CRP and IL-6 in the serum of patients in the DVT group compared to those in the non-DVT group (P < .05). Furthermore, combined testing of CRP and IL-6 exhibited heightened sensitivity (0.85%), specificity (0.917%), and area under the curve (AUC) (0.952) compared to single-parameter testing alone, indicating its superiority in diagnosing postoperative DVT.

Conclusions: The combination of CRP and IL-6 testing presents a promising diagnostic strategy for identifying postoperative DVT in endometrial cancer patients. Implementing this approach in clinical practice could facilitate early detection and prompt management of DVT, thereby potentially reducing associated morbidity and mortality.

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利用 CRP 和 IL-6 联合检测子宫内膜癌术后深静脉血栓检测，提高诊断精确度。

背景：深静脉血栓是手术后常见的并发症，尤其是在癌症患者中，因此需要有效的诊断方法以便及时干预：本研究旨在探讨结合 C 反应蛋白（CRP）和白细胞介素-6（IL-6）检测诊断子宫内膜癌术后深静脉血栓（DVT）的可能性：方法：选取2018年3月至2022年3月期间河北医科大学第一医院收治的60例子宫内膜癌术后发生深静脉血栓的患者组成深静脉血栓组。此外，同期接受子宫内膜癌手术但未发生深静脉血栓的60名患者组成非深静脉血栓组。采用可靠的实验室技术对两组患者的血清 CRP 和 IL-6 水平进行量化和比较。随后，评估了单参数检测（CRP 或 IL-6）与联合检测（CRP 和 IL-6）对术后深静脉血栓的诊断准确性：结果：分析显示，与非深静脉血栓组相比，深静脉血栓组患者血清中的 CRP 和 IL-6 水平明显升高（P < .05）。此外，与单参数检测相比，联合检测 CRP 和 IL-6 的敏感性（0.85%）、特异性（0.917%）和曲线下面积（AUC）（0.952）均有所提高，表明其在诊断术后深静脉血栓方面更具优势：结论：结合CRP和IL-6检测是一种很有前景的诊断策略，可用于识别子宫内膜癌患者术后深静脉血栓。在临床实践中采用这种方法可促进深静脉血栓的早期发现和及时处理，从而有可能降低相关的发病率和死亡率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alternative therapies in health and medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

0.90

自引率

0.00%

发文量

219

期刊介绍： Launched in 1995, Alternative Therapies in Health and Medicine has a mission to promote the art and science of integrative medicine and a responsibility to improve public health. We strive to maintain the highest standards of ethical medical journalism independent of special interests that is timely, accurate, and a pleasure to read. We publish original, peer-reviewed scientific articles that provide health care providers with continuing education to promote health, prevent illness, and treat disease. Alternative Therapies in Health and Medicine was the first journal in this field to be indexed in the National Library of Medicine. In 2006, 2007, and 2008, ATHM had the highest impact factor ranking of any independently published peer-reviewed CAM journal in the United States—meaning that its research articles were cited more frequently than any other journal’s in the field. Alternative Therapies in Health and Medicine does not endorse any particular system or method but promotes the evaluation and appropriate use of all effective therapeutic approaches. Each issue contains a variety of disciplined inquiry methods, from case reports to original scientific research to systematic reviews. The editors encourage the integration of evidence-based emerging therapies with conventional medical practices by licensed health care providers in a way that promotes a comprehensive approach to health care that is focused on wellness, prevention, and healing. Alternative Therapies in Health and Medicine hopes to inform all licensed health care practitioners about developments in fields other than their own and to foster an ongoing debate about the scientific, clinical, historical, legal, political, and cultural issues that affect all of health care.