Transcriptomic profiling revealed immune-related signaling pathways in response to experimental infection of Leishmania donovani in two desert lizards from Northwest China

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-03-26 DOI:10.1016/j.dci.2024.105173

Yuying Xiao , Jinlei He , Xianguang Guo , Xiaoting Zheng , Zheying Zhu , Qi Zhou , Xuechun Liao , Dali Chen

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Abstract

Little is known about the immune response of lizards to Leishmania parasties. In this study, we conducted the first liver transcriptome analysis of two lizards (Phrynocephalus przewalskii and Eremias multiocellata) challenged with L. donovani, endemic to the steppe desert region of northwestern China. Our results revealed that multiple biological processes and immune-related signaling pathways are closely associated with the immune response to experimental L. donovani infection in the two lizards, and that both lizards show similar changes to mammals in terms of immunity to Leishmania. However, the interspecific divergence of the two lizards leads to different transcriptomic changes. In particular, in contrast to P. przewalskii, the challenged E. mutltiocellata was characterized by the induction of down-regulation of most DEGs. These findings will contribute to the scarce resources on lizard immunity and provide a reference for further research on immune mechanisms in reptiles.

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转录组分析揭示了中国西北地区两只沙漠蜥蜴对实验性唐氏利什曼原虫感染的免疫相关信号通路。

人们对蜥蜴对利什曼原虫的免疫反应知之甚少。在这项研究中，我们首次对中国西北部草原沙漠地区特有的两种蜥蜴（Phrynocephalus przewalskii和Eremias multiocellata）进行了肝脏转录组分析。我们的研究结果表明，两种蜥蜴对实验性L. donovani感染的免疫反应与多种生物学过程和免疫相关信号通路密切相关，两种蜥蜴对利什曼原虫的免疫力与哺乳动物表现出相似的变化。然而，两种蜥蜴的种间差异导致了不同的转录组变化。特别是，与P. przewalskii相比，受到挑战的E. mutltiocellata的特点是诱导大多数DEGs下调。这些发现将为蜥蜴免疫方面的稀缺资源做出贡献，并为进一步研究爬行动物的免疫机制提供参考。

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