A Mechanism for the Treatment of Cardiovascular and Renal Disease: TRPV1 and TRPA1.

IF 2.6 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Journal of Cardiovascular Pharmacology Pub Date : 2024-07-01 DOI:10.1097/FJC.0000000000001562

Lu Gao, Qi Wang, Min-Yi Li, Meng-Meng Zhang, Bin Wang, Tai-Wei Dong, Pei-Feng Wei, Min Li

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Abstract

Abstract: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally. CVD and kidney disease are closely related, with kidney injury increasing CVD mortality. The pathogenesis of cardiovascular and renal diseases involves complex and diverse interactions between multiple extracellular and intracellular signaling molecules, among which transient receptor potential vanilloid 1 (TRPV1)/transient receptor potential ankyrin 1 (TRPA1) channels have received increasing attention. TRPV1 belongs to the vanilloid receptor subtype family of transient receptor potential ion channels, and TRPA1 belongs to the transient receptor potential channel superfamily. TRPV1/TRPA1 are jointly involved in the management of cardiovascular and renal diseases and play important roles in regulating vascular tension, promoting angiogenesis, antifibrosis, anti-inflammation, and antioxidation. The mechanism of TRPV1/TRPA1 is mainly related to regulation of intracellular calcium influx and release of nitric oxide and calcitonin gene-related peptide. Therefore, this study takes the TRPV1/TRPA1 channel as the research object, analyzes and summarizes the process and mechanism of TRPV1/TRPA1 affecting cardiovascular and renal diseases, and lays a foundation for the treatment of cardiorenal diseases.

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治疗心血管和肾脏疾病的机制。

心血管疾病（CVD）是全球发病和死亡的主要原因。心血管疾病和肾脏疾病密切相关，肾脏损伤会增加心血管疾病的死亡率。心血管疾病和肾脏疾病的发病机制涉及多种细胞外和细胞内信号分子之间复杂多样的相互作用，其中瞬时受体电位类香草素 1（TRPV1）/瞬时受体电位钝角蛋白 1（TRPA1）通道受到越来越多的关注。TRPV1 属于瞬态受体电位（TRP）离子通道的香草素受体亚型家族，而 TRPA1 则属于 TRP 通道超家族。TRPV1/TRPA1 共同参与心血管和肾脏疾病的治疗，在调节血管张力、促进血管生成、抗纤维化、抗炎和抗氧化等方面发挥重要作用。TRPV1 / TRPA1的作用机制主要与调节细胞内钙离子流入、释放一氧化氮（NO）和降钙素基因相关肽（CGRP）有关。因此，本研究以TRPV1 / TRPA1通道为研究对象，分析和总结TRPV1 / TRPA1影响心血管和肾脏疾病的过程和机制，为心肾疾病的治疗奠定基础。

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来源期刊

Journal of Cardiovascular Pharmacology 医学-心血管系统

CiteScore

5.10

自引率

3.30%

发文量

367

审稿时长

1 months

期刊介绍： Journal of Cardiovascular Pharmacology is a peer reviewed, multidisciplinary journal that publishes original articles and pertinent review articles on basic and clinical aspects of cardiovascular pharmacology. The Journal encourages submission in all aspects of cardiovascular pharmacology/medicine including, but not limited to: stroke, kidney disease, lipid disorders, diabetes, systemic and pulmonary hypertension, cancer angiogenesis, neural and hormonal control of the circulation, sepsis, neurodegenerative diseases with a vascular component, cardiac and vascular remodeling, heart failure, angina, anticoagulants/antiplatelet agents, drugs/agents that affect vascular smooth muscle, and arrhythmias. Appropriate subjects include new drug development and evaluation, physiological and pharmacological bases of drug action, metabolism, drug interactions and side effects, application of drugs to gain novel insights into physiology or pathological conditions, clinical results with new and established agents, and novel methods. The focus is on pharmacology in its broadest applications, incorporating not only traditional approaches, but new approaches to the development of pharmacological agents and the prevention and treatment of cardiovascular diseases. Please note that JCVP does not publish work based on biological extracts of mixed and uncertain chemical composition or unknown concentration.