{"title":"Surface zeta potential and protein adsorption on the coating surface of a heteroarm star polymer with a controlled hydrophilic/hydrophobic arm ratio","authors":"Masayasu Totani, Hiroharu Ajiro, Jun-ichi Kadokawa, Masao Tanihara, Tsuyoshi Ando","doi":"10.1038/s41428-024-00911-y","DOIUrl":null,"url":null,"abstract":"A surface coated with a star polymer is believed to form a highly dense polymer brush-like architecture and inhibit biofouling. In this study, the surface properties of the star polymer coating were evaluated with their resistance to protein adsorption and surface zeta (ζ)-potential to clarify the mechanism for inhibition of cell adhesion. The surface of the star polymer coating with a high density of poly(2-hydroxyethyl methacrylate) (PHEMA) formed an electrically neutral diffuse brush structure in water and showed high resistance to protein adsorption. Considering the data obtained in the study, the surface ζ-potential and antibiofouling properties were correlated by controlling the molecular architecture of the coating material. The surface properties of the star polymer coating were evaluated with their resistance to protein adsorption and surface zeta (ζ)-potential to clarify the mechanism for inhibition of cell adhesion. The surface of the star polymer coating with a high density of poly(2-hydroxyethyl methacrylate) formed an electrically neutral diffuse brush structure in water and showed high resistance to protein adsorption. Considering the data obtained in the study, the surface ζ-potential and antibiofouling properties were correlated by controlling the molecular architecture of the coating material.","PeriodicalId":20302,"journal":{"name":"Polymer Journal","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polymer Journal","FirstCategoryId":"92","ListUrlMain":"https://www.nature.com/articles/s41428-024-00911-y","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0
Abstract
A surface coated with a star polymer is believed to form a highly dense polymer brush-like architecture and inhibit biofouling. In this study, the surface properties of the star polymer coating were evaluated with their resistance to protein adsorption and surface zeta (ζ)-potential to clarify the mechanism for inhibition of cell adhesion. The surface of the star polymer coating with a high density of poly(2-hydroxyethyl methacrylate) (PHEMA) formed an electrically neutral diffuse brush structure in water and showed high resistance to protein adsorption. Considering the data obtained in the study, the surface ζ-potential and antibiofouling properties were correlated by controlling the molecular architecture of the coating material. The surface properties of the star polymer coating were evaluated with their resistance to protein adsorption and surface zeta (ζ)-potential to clarify the mechanism for inhibition of cell adhesion. The surface of the star polymer coating with a high density of poly(2-hydroxyethyl methacrylate) formed an electrically neutral diffuse brush structure in water and showed high resistance to protein adsorption. Considering the data obtained in the study, the surface ζ-potential and antibiofouling properties were correlated by controlling the molecular architecture of the coating material.
期刊介绍:
Polymer Journal promotes research from all aspects of polymer science from anywhere in the world and aims to provide an integrated platform for scientific communication that assists the advancement of polymer science and related fields. The journal publishes Original Articles, Notes, Short Communications and Reviews.
Subject areas and topics of particular interest within the journal''s scope include, but are not limited to, those listed below:
Polymer synthesis and reactions
Polymer structures
Physical properties of polymers
Polymer surface and interfaces
Functional polymers
Supramolecular polymers
Self-assembled materials
Biopolymers and bio-related polymer materials
Polymer engineering.