Modulation of plasmacytoid dendritic cells response in inflammation and autoimmunity

IF 7.5 2区 医学 Q1 IMMUNOLOGY Immunological Reviews Pub Date : 2024-03-29 DOI:10.1111/imr.13331
Marie Dominique Ah Kioon, Paôline Laurent, Vidyanath Chaudhary, Yong Du, Mary K. Crow, Franck J. Barrat
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Abstract

The discovery of toll-like receptors (TLRs) and the subsequent recognition that endogenous nucleic acids (NAs) could serve as TLR ligands have led to essential insights into mechanisms of healthy immune responses as well as pathogenic mechanisms relevant to systemic autoimmune and inflammatory diseases. In systemic lupus erythematosus, systemic sclerosis, and rheumatoid arthritis, NA-containing immune complexes serve as TLR ligands, with distinct implications depending on the additional immune stimuli available. Plasmacytoid dendritic cells (pDCs), the robust producers of type I interferon (IFN-I), are providing critical insights relevant to TLR-mediated healthy immune responses and tissue repair, as well as generation of inflammation, autoimmunity and fibrosis, processes central to the pathogenesis of many autoimmune diseases. In this review, we describe recent data characterizing the role of platelets and NA-binding chemokines in modulation of TLR signaling in pDCs, as well as implications for how the IFN-I products of pDCs contribute to the generation of inflammation and wound healing responses by monocyte/macrophages. Chemokine modulators of TLR-mediated B cell tolerance mechanisms and interactions between TLR signaling and metabolic pathways are also considered. The modulators of TLR signaling and their contribution to the pathogenesis of systemic autoimmune diseases suggest new opportunities for identification of novel therapeutic targets.

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在炎症和自身免疫中调节浆细胞树突状细胞的反应。
收费样受体(TLR)的发现以及随后对内源性核酸(NAs)可作为 TLR 配体的认识,使人们对健康免疫反应机制以及与全身性自身免疫性和炎症性疾病相关的致病机制有了重要的认识。在系统性红斑狼疮、系统性硬化症和类风湿性关节炎中,含有 NA 的免疫复合物可作为 TLR 配体,其不同的影响取决于额外的免疫刺激。类质体树突状细胞(pDCs)是Ⅰ型干扰素(IFN-I)的强力制造者,它们提供了与 TLR 介导的健康免疫反应和组织修复以及炎症、自身免疫和纤维化(许多自身免疫性疾病发病机制的核心过程)的产生有关的重要见解。在这篇综述中,我们将介绍血小板和 NA 结合型趋化因子在调节 pDC 的 TLR 信号转导中的作用的最新数据,以及 pDC 的 IFN-I 产物如何促进单核细胞/巨噬细胞产生炎症和伤口愈合反应的影响。此外,还研究了 TLR 介导的 B 细胞耐受机制的趋化因子调节剂以及 TLR 信号传导与代谢途径之间的相互作用。TLR 信号的调节因子及其对全身性自身免疫性疾病发病机制的贡献,为确定新的治疗靶点提供了新的机会。
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来源期刊
Immunological Reviews
Immunological Reviews 医学-免疫学
CiteScore
16.20
自引率
1.10%
发文量
118
审稿时长
4-8 weeks
期刊介绍: Immunological Reviews is a specialized journal that focuses on various aspects of immunological research. It encompasses a wide range of topics, such as clinical immunology, experimental immunology, and investigations related to allergy and the immune system. The journal follows a unique approach where each volume is dedicated solely to a specific area of immunological research. However, collectively, these volumes aim to offer an extensive and up-to-date overview of the latest advancements in basic immunology and their practical implications in clinical settings.
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