Evaluation of the Simple Suspension Method for Oral Anticancer Drugs.

IF 0.3 4区医学 Q4 PHARMACOLOGY & PHARMACY Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Pub Date : 2024-01-01 DOI:10.1248/yakushi.23-00194

Tomoya Abe, Sanae Kusakabe, Miho Naoi, Takayuki Suzuki, Atsunobu Sagara, Makoto Hiraide, Motohiko Sano, Toshiaki Nakayama

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Abstract

The simple suspension method (SSM) involves administering tablets or capsules using a tube after disintegration and suspension in hot water without crushing or opening the capsule. Particularly, for anticancer drugs, it is an excellent method of administration that reduces the risk of exposure during dispensing. In contrast, information on SSM for individual drugs is insufficient. Anticancer drugs present a therapeutic challenge because their information is limited. We investigated whether SSM is possible with 36 anticancer drugs. Furthermore, we examined the pH of the suspension of these drugs, for which no information on SSM is available. We found that suspension was possible for 24 of the 36 drugs. Furthermore, the pH of the suspension was measured, which provided important information when considering dissolution solutions other than hot water. Little changes in the pH were observed before or after passing through the tube. The results of this study may improve medication adherence in patients with cancer experiencing dysphagia.

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评估口服抗癌药物的简易悬浮法

简易混悬法（SSM）是指将药片或胶囊在热水中崩解和混悬后，在不压碎或不打开胶囊的情况下用导管给药。特别是对抗癌药物而言，这是一种极好的给药方法，可降低配药过程中的暴露风险。相比之下，有关个别药物 SSM 的信息尚不充分。由于抗癌药物的信息有限，因此对其治疗提出了挑战。我们研究了 36 种抗癌药物是否可以进行 SSM。此外，我们还研究了这些药物悬浮液的 pH 值，因为没有关于 SSM 的信息。我们发现，36 种药物中有 24 种可以悬浮。此外，我们还测量了悬浮液的 pH 值，这在考虑热水以外的溶解溶液时提供了重要信息。在通过试管前后，pH 值几乎没有变化。这项研究的结果可能会改善存在吞咽困难的癌症患者的服药依从性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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