{"title":"Efficacy of a Comprehensive Weight Reduction Intervention in Male Adolescents With Different FTO Genotypes","authors":"Zahra Roumi, Zahra Salimi, Zahra Mahmoudi, Khadijeh Abbasi Mobarakeh, Maryam Ladaninezhad, Mobina Zeinalabedini, Mohammad Keshavarz Mohammadian, Ali Shamsi-Goushki, Zahra Saeedirad, Bojlul Bahar, Sara Khoshdooz, Naser Kalantari, Ghasem Azizi Tabesh, Saeid Doaei, Maryam Gholamalizadeh","doi":"10.1002/edm2.483","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>The <i>FTO</i> gene polymorphisms may influence the effects of lifestyle interventions on obesity. The present study aimed to assess the influence of the rs9930506 <i>FTO</i> gene polymorphism on the success of a comprehensive weight loss intervention in male adolescents with overweight and obesity.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This study was carried out on 96 adolescent boys with overweight and obesity who were randomly assigned to the intervention (<i>n</i> = 53) and control (<i>n</i> = 43) groups. The blood samples of the participants were collected, and the <i>FTO</i> gene was genotyped for the rs9930506 polymorphism. A comprehensive lifestyle intervention including changes in diet and physical activity was performed for 8 weeks in the intervention group.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Following the lifestyle intervention, BMI and fat mass decreased significantly in the intervention group compared with the control group (both <i>p</i> < 0.05), while no change was found in weight, height or body muscle percentage between the groups. The participants in the intervention group with the AA/AG genotype and not in carriers of the GG genotype had a significantly higher reduction in BMI (−1.21 vs. 1.87 kg/m<sup>2</sup>, <i>F</i> = 4.07, <i>p</i> < 0.05) compared with the control group.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The intervention in individuals with the AA/AG genotype has been significantly effective in weight loss compared with the control group. The intervention had no association effect on anthropometric indices in adolescents with the GG genotype of the <i>FTO</i> rs9930506 polymorphism.</p>\n </section>\n \n <section>\n \n <h3> Trial Registration</h3>\n \n <p>Name of the registry: National Nutrition and Food Technology Research Institute; Trial registration number: IRCT2016020925699N2; Date of registration: 24/04/2016; URL of trial registry record: https://www.irct.ir/trial/21447</p>\n </section>\n </div>","PeriodicalId":36522,"journal":{"name":"Endocrinology, Diabetes and Metabolism","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/edm2.483","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrinology, Diabetes and Metabolism","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/edm2.483","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
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Abstract
Background
The FTO gene polymorphisms may influence the effects of lifestyle interventions on obesity. The present study aimed to assess the influence of the rs9930506 FTO gene polymorphism on the success of a comprehensive weight loss intervention in male adolescents with overweight and obesity.
Methods
This study was carried out on 96 adolescent boys with overweight and obesity who were randomly assigned to the intervention (n = 53) and control (n = 43) groups. The blood samples of the participants were collected, and the FTO gene was genotyped for the rs9930506 polymorphism. A comprehensive lifestyle intervention including changes in diet and physical activity was performed for 8 weeks in the intervention group.
Results
Following the lifestyle intervention, BMI and fat mass decreased significantly in the intervention group compared with the control group (both p < 0.05), while no change was found in weight, height or body muscle percentage between the groups. The participants in the intervention group with the AA/AG genotype and not in carriers of the GG genotype had a significantly higher reduction in BMI (−1.21 vs. 1.87 kg/m2, F = 4.07, p < 0.05) compared with the control group.
Conclusion
The intervention in individuals with the AA/AG genotype has been significantly effective in weight loss compared with the control group. The intervention had no association effect on anthropometric indices in adolescents with the GG genotype of the FTO rs9930506 polymorphism.
Trial Registration
Name of the registry: National Nutrition and Food Technology Research Institute; Trial registration number: IRCT2016020925699N2; Date of registration: 24/04/2016; URL of trial registry record: https://www.irct.ir/trial/21447
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