The effects of TiO2, ZnO, IONs and Al2O3 metallic nanoparticles on the CYP1A1 and NBN transcripts in rat liver.

IF 2.2 4区医学 Q3 TOXICOLOGY Toxicology Research Pub Date : 2024-03-28 eCollection Date: 2024-04-01 DOI:10.1093/toxres/tfae034

Walaa A Moselhy, Marwa A Ibrahim, Ahlam G Khalifa, El-Shaymaa El-Nahass, Nour El-Houda Y Hassan

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Abstract

Introduction: Metal oxide nanoparticles are currently used widely in many aspects of human and animal life with broad prospects for biomedical purposes. The present work was carried out to investigate the effects of orally administrated TiO2NPs, ZnONPs, IONs and Al₂O₃NPs on the mRNA expression level of CYP 1A1 and NBN in the rat liver.

Materials and methods: Four groups of male Albino rats were given their respective treatment orally for 60 days in a dose of 1/20 of the LD50 TiO2NPs (600 mg/Kg b.wt/day), ZnONPs (340 mg/Kg b.wt/day), IONs (200 mg/kg b.wt/day) and Al₂O₃NPs (100 mg/Kg b.wt/day) and a fifth group served as a control group.

Rresults: The mRNA level of CYP 1A1 and NBN showed up-regulation in all the NPs-treated groups relative to the control group. ZnONPs group recorded the highest expression level while the TiO2NPs group showed the lowest expression level transcript. Conclusion:The toxic effects produced by these nanoparticles were more pronounced in the case of zinc oxide, followed by aluminum oxide, iron oxide nanoparticles and titanium dioxide, respectively.

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TiO2、ZnO、离子和 Al2O3 金属纳米粒子对大鼠肝脏中 CYP1A1 和 NBN 转录本的影响。

导言：金属氧化物纳米粒子目前已广泛应用于人类和动物生活的许多方面，具有广阔的生物医学前景。本研究旨在探讨口服 TiO2NPs、ZnONPs、IONs 和 Al2O3NPs 对大鼠肝脏中 CYP 1A1 和 NBN mRNA 表达水平的影响：给四组雄性白化大鼠口服各自的治疗剂量，剂量为LD50的1/20，分别为TiO2NPs（600毫克/千克体重/天）、ZnONPs（340毫克/千克体重/天）、IONs（200毫克/千克体重/天）和Al2O3NPs（100毫克/千克体重/天），为期60天，第五组为对照组：结果：与对照组相比，所有 NPs 处理组的 CYP 1A1 和 NBN mRNA 水平均出现上调。ZnONPs 组的表达水平最高，而 TiO2NPs 组的表达水平最低。结论：这些纳米粒子产生的毒性效应在氧化锌中更为明显，其次分别是氧化铝、氧化铁纳米粒子和二氧化钛。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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