Deep partially linear cox model for current status data.

IF 1.4 4区 数学 Q3 BIOLOGY Biometrics Pub Date : 2024-03-27 DOI:10.1093/biomtc/ujae024
Qiang Wu, Xingwei Tong, Xingqiu Zhao
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Abstract

Deep learning has continuously attained huge success in diverse fields, while its application to survival data analysis remains limited and deserves further exploration. For the analysis of current status data, a deep partially linear Cox model is proposed to circumvent the curse of dimensionality. Modeling flexibility is attained by using deep neural networks (DNNs) to accommodate nonlinear covariate effects and monotone splines to approximate the baseline cumulative hazard function. We establish the convergence rate of the proposed maximum likelihood estimators. Moreover, we derive that the finite-dimensional estimator for treatment covariate effects is $\sqrt{n}$-consistent, asymptotically normal, and attains semiparametric efficiency. Finally, we demonstrate the performance of our procedures through extensive simulation studies and application to real-world data on news popularity.

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针对现状数据的深度部分线性 Cox 模型。
深度学习在多个领域不断取得巨大成功,但其在生存数据分析中的应用仍然有限,值得进一步探索。为分析现状数据,我们提出了一种深度部分线性 Cox 模型,以规避维度诅咒。通过使用深度神经网络(DNN)来适应非线性协变量效应,并使用单调样条来近似基线累积危险函数,从而实现建模的灵活性。我们确定了所提出的最大似然估计值的收敛率。此外,我们还推导出治疗协变量效应的有限维估计器是$\sqrt{n}$一致的、渐近正态的,并且达到了半参数效率。最后,我们通过大量的模拟研究并应用于现实世界的新闻流行度数据,证明了我们的程序的性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biometrics
Biometrics 生物-生物学
CiteScore
2.70
自引率
5.30%
发文量
178
审稿时长
4-8 weeks
期刊介绍: The International Biometric Society is an international society promoting the development and application of statistical and mathematical theory and methods in the biosciences, including agriculture, biomedical science and public health, ecology, environmental sciences, forestry, and allied disciplines. The Society welcomes as members statisticians, mathematicians, biological scientists, and others devoted to interdisciplinary efforts in advancing the collection and interpretation of information in the biosciences. The Society sponsors the biennial International Biometric Conference, held in sites throughout the world; through its National Groups and Regions, it also Society sponsors regional and local meetings.
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