Differences in choroidal responses to near work between myopic children and young adults.

IF 4.1 1区医学 Q1 OPHTHALMOLOGY Eye and Vision Pub Date : 2024-04-02 DOI:10.1186/s40662-024-00382-5

Mengqi Liu, Yuanyuan Wang, Haoer Li, Yunpeng Zhao, Min Ma, Shihan Xu, Xiaohuan Wei, Ruiyan Xu, Ruikang Tian, Xiangtian Zhou, Hao Wu

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Abstract

Background: Near work is generally considered as a risk factor for myopia onset and progression. This study aimed to investigate the choroidal responses to a brief-period of near work in children and young adults.

Methods: Thirty myopic medical students (aged 18-28 years) and 30 myopic children (aged 8-12 years) participated in this study. The submacular total choroidal area (TCA), luminal area (LA), stromal area (SA), choroidal vascularity index (CVI) and choriocapillaris flow deficit (CcFD), as well as subfoveal choroidal thickness (SFCT) were measured with swept-source optical coherence tomography/optical coherence tomography angiography (SS-OCT/OCTA) before and immediately after 20 min, 40 min, 60 min of near work at a distance of 33 cm.

Results: In adults, 20 min of near work induced a significant reduction in SFCT (- 5.1 ± 6.5 μm), LA [(- 19.2 ± 18.6) × 10³ μm²], SA [(- 8.2 ± 12.6) × 10³ μm²] and TCA [(- 27.4 ± 24.9) × 10³ μm²] (all P < 0.01). After 40 min of near work, LA was still reduced [(- 9.4 ± 18.3) × 10³ μm²], accompanied with a decreased CVI (- 0.39% ± 0.70%) and an increased CcFD (0.30% ± 0.78%) (all P < 0.05). After 60 min of near work, CVI was still reduced (- 0.28% ± 0.59%), and CcFD was still increased (0.37% ± 0.75%) (all P < 0.05). In children, 20 min of near work induced a significant increase in CcFD (0.55% ± 0.64%), while 60 min of near work induced increases in SA [(7.2 ± 13.0) × 10³ μm²] and TCA [(9.7 ± 25.3) × 10³ μm²] and a reduction in CVI (- 0.28% ± 0.72%) (all P < 0.05). Children exhibited lower near work-induced LA and TCA reduction than adults, with a mean difference of - 0.86% and - 0.82%, respectively (all P < 0.05).

Conclusions: The temporal characteristics and magnitude of changes of choroidal vascularity and choriocapillaris perfusion during near work was not identical between children and adults. The initial response to near work was observed in choriocapillaris in children, whereas it was observed in the medium- and large-sized vessels in adults.

Trial registration: Clinical Trial Registry (ChiCTR), ChiCTR2000040205. Registered on 25 November 2020, https://www.chictr.org.cn/bin/project/edit?pid=64501 .

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近视儿童和青少年对近距离工作的脉络膜反应存在差异。

背景：近距离工作通常被认为是近视发生和发展的风险因素。本研究旨在调查儿童和青少年对短暂近距离工作的脉络膜反应：方法：30 名近视医学生（18-28 岁）和 30 名近视儿童（8-12 岁）参加了这项研究。方法：30 名近视医学生（18-28 岁）和 30 名近视儿童（8-12 岁）参加了这项研究。在距离 33 厘米处进行 20 分钟、40 分钟和 60 分钟的近距离工作之前和之后，分别用扫源光学相干断层成像/光学相干断层血管成像（SS-OCT/OCTA）测量了脉络膜下总面积（TCA）、管腔面积（LA）、基质面积（SA）、脉络膜血管指数（CVI）和绒毛膜血流缺损（CcFD）以及脉络膜下厚度（SFCT）。结果：在成人中，20 分钟的近距离工作导致 SFCT（- 5.1 ± 6.5 μm）、LA[（- 19.2 ± 18.6）×103 μm2]、SA[（- 8.2 ± 12.6）×103 μm2]和 TCA[（- 27.4 ± 24.9）×103 μm2]（均为 P 3 μm2]，同时伴有 CVI 下降（- 0.39% ± 0.70%）和 CcFD 增加（0.30% ± 0.78%）（均为 P 3 μm2]，以及 TCA [（9.7 ± 25.3）×103 μm2]和 CVI 下降（- 0.28% ± 0.72%）（均为 P 结论：儿童和成人在近距离工作时脉络膜血管和绒毛膜灌注变化的时间特征和幅度并不相同。儿童脉络膜对近距离工作的最初反应出现在脉络膜瓣，而成人则出现在中型和大型血管：试验注册：临床试验注册中心（ChiCTR），ChiCTR2000040205。注册日期：2020 年 11 月 25 日，https://www.chictr.org.cn/bin/project/edit?pid=64501 。

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来源期刊

Eye and Vision OPHTHALMOLOGY-

CiteScore

8.60

自引率

2.40%

发文量

审稿时长

15 weeks

期刊介绍： Eye and Vision is an open access, peer-reviewed journal for ophthalmologists and visual science specialists. It welcomes research articles, reviews, methodologies, commentaries, case reports, perspectives and short reports encompassing all aspects of eye and vision. Topics of interest include but are not limited to: current developments of theoretical, experimental and clinical investigations in ophthalmology, optometry and vision science which focus on novel and high-impact findings on central issues pertaining to biology, pathophysiology and etiology of eye diseases as well as advances in diagnostic techniques, surgical treatment, instrument updates, the latest drug findings, results of clinical trials and research findings. It aims to provide ophthalmologists and visual science specialists with the latest developments in theoretical, experimental and clinical investigations in eye and vision.