Clinical Profile and Outcome of Organophosphorus Poisoning in a Tertiary Hospital.

Mymensingh medical journal : MMJ Pub Date : 2024-04-01
M A Hosen, M M Faysal, J Khanam, B Khan, F Ahamed, M E H Khan
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Abstract

Organophosphorus compound (OPC) poisoning is common in Bangladesh. The toxicity of the agent and paucity of appropriate medical services has resulted in high mortality rates. To find out the clinical profile and outcome of OPC poisoning patients is the main aim of my study. This descriptive cross-sectional study was conducted in the Department of Medicine, Mymensingh Medical College Hospital, Bangladesh from September 2016 to November 2018. In this study, mean age of the study subjects was 25.90±11.24 years. Males (70.8%) were predominant than female (29.2%). In this study, most of the poisoning was done by ingestion (98.3%) and only two (1.7%) by inhalation. Regarding features, most muscarinic effect was constricted pupil and bronchospasm (65.0%). Common nicotinic effect was fasciculation (25.0%) and central effect was headache (61.67%). Mean amount of OPC ingestion was 26.30±17.24 ml in this study. Regarding circumstances of poisoning, familial disharmony (38.3%) and quarrel with other family members (37.5%) were the major reason followed by failure of personal affairs (15.0%) and other reasons (9.2%). Regarding complications, aspiration pneumonia was found in 6.7% cases, cardiac arrhythmia was in 6.7% cases and intermediate syndrome was in 1.7% cases. Most of the study subjects (95.0%) recovered fully. Most of the patients were from rural area. Suicidal was the common motive and familial disharmony and quarrel with other family members are the common circumstances of poisoning. Mortality rate was 5.0%.

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一家三级甲等医院的有机磷中毒临床概况和结果。
有机磷化合物(OPC)中毒在孟加拉国很常见。有机磷化合物的毒性和缺乏适当的医疗服务导致了很高的死亡率。本研究的主要目的是了解有机磷化合物中毒患者的临床概况和预后。这项描述性横断面研究于 2016 年 9 月至 2018 年 11 月在孟加拉国迈门辛医学院医院医学系进行。在这项研究中,研究对象的平均年龄为(25.90±11.24)岁。男性(70.8%)多于女性(29.2%)。在本研究中,大多数中毒是通过摄入(98.3%)引起的,只有2例(1.7%)是通过吸入引起的。就特征而言,大多数毒蕈碱效应是瞳孔收缩和支气管痉挛(65.0%)。常见的烟碱效应是筋膜收缩(25.0%),中枢效应是头痛(61.67%)。本研究中摄入 OPC 的平均量为 26.30±17.24 毫升。关于中毒情况,家庭不和(38.3%)和与其他家庭成员争吵(37.5%)是主要原因,其次是个人事务失败(15.0%)和其他原因(9.2%)。在并发症方面,6.7%的病例出现吸入性肺炎,6.7%的病例出现心律失常,1.7%的病例出现中间综合征。大多数研究对象(95.0%)完全康复。大多数患者来自农村地区。自杀是常见的中毒动机,家庭不和以及与其他家庭成员争吵是常见的中毒情况。死亡率为 5.0%。
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