Survival rate and death risk for associated pulmonary arterial hypertension: A retrospective population-based study

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-03-31 DOI:10.23838/pfm.2023.00142

Sujin Kim, Shin Yi Jang, Soo Yeon Lee, S. Seo, S. Yi, C. Lee, Eun Jeong Cho, Kyeongsug Kim

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Abstract

Purpose: This study aimed to assess the survival rate (SR) and death risk for associated pulmonary arterial hypertension (aPAH; 10th revision of the International Statistical Classification of Diseases [ICD-10], I27.2) in Koreans.Methods: The data were collected from the Korean National Health Insurance Service from 2006 through 2017 (n= 15,448). We analyzed the SR using the Kaplan-Meier method and carried out Cox proportional hazards analyses.Results: Patients’ mean age upon aPAH diagnosis was 60.1±24.0 years, and 60.7% of the patients were female. The 10-year SR of aPAH was 46.3% (95% confidence interval, 45.0 to 47.6). The factors associated with an increase in the adjusted death risk included age of 0 to 9 years, advancing age, male sex, lower income level, and comorbidities including diabetes mellitus, myocardial infarction, heart failure, hemorrhagic stroke, chronic kidney disease, malignant neoplasm, hereditary hemorrhagic telangiectasia, and systemic lupus erythematosus.Conclusion: The 10-year SR of aPAH was over 46%. The risk of death from aPAH was significantly higher with advancing age, sex, lower income level, and comorbidities.

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伴发肺动脉高压的存活率和死亡风险：基于人群的回顾性研究

目的：本研究旨在评估韩国人伴发肺动脉高压（aPAH；国际疾病统计分类[ICD-10]第10次修订版，I27.2）的存活率（SR）和死亡风险：数据收集自2006年至2017年的韩国国民健康保险服务机构（n= 15448）。我们使用 Kaplan-Meier 法分析了 SR，并进行了 Cox 比例危险度分析：结果：确诊为高血压的患者平均年龄为（60.1±24.0）岁，60.7%的患者为女性。10 年的 aPAH SR 为 46.3%（95% 置信区间为 45.0 至 47.6）。与调整后死亡风险增加相关的因素包括年龄在0至9岁之间、年龄增大、男性、收入水平较低以及合并症，包括糖尿病、心肌梗死、心力衰竭、出血性中风、慢性肾病、恶性肿瘤、遗传性出血性毛细血管扩张症和系统性红斑狼疮：结论：高血压性心脏病的 10 年死亡率超过 46%。结论：高血压肾病的 10 年死亡率超过 46%，年龄越大、性别越高、收入越低、合并症越多，死于高血压肾病的风险就越高。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.