Solubility Studies of Amlodipine Besylate in Propylene Glycol + Ethanol Mixtures at Different Temperatures

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-03-31 DOI:10.1007/s10953-024-01373-9

Homa Rezaei, Nastaran Hashemzadeh, Elaheh Rahimpour, Fleming Martinez, Abolghasem Jouyban

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Abstract

In this research, the solubility of amlodipine besylate was studied in the propylene glycol + ethanol mixtures at different temperatures (293.2–313.2 K). The study showed that the solubility increases with an increase in propylene glycol concentration, reaching its highest point at w₁ = 0.8. Additionally, the solubility values have a positive correlation with temperature, which is typical for the solid solutes. The experimental solubility data were correlated with some well known cosolvency models and the accuracy of these models was investigated with the mean relative deviations (MRDs%) of the back-calculated data. MRDs were 1.2% for the van’t Hoff model, 4.3 and 4.6% for the Jouyban–Acree and Jouyban–Acree–van’t Hoff equations, 1.4% for the MRS model and 2.1% for the modified Wilson model. The apparent thermodynamic parameters (standard state Gibbs energy, enthalpy, and entropy) of dissolution of ADB in the non-aqueous saturated mixtures were also calculated with the van’t Hoff and Gibbs equations at T_hm = 303.0 K.

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不同温度下苯磺酸氨氯地平在丙二醇和乙醇混合物中的溶解度研究

本研究对不同温度（293.2-313.2 K）下苯磺酸氨氯地平在丙二醇+乙醇混合物中的溶解度进行了研究。研究表明，溶解度随着丙二醇浓度的增加而增加，在 w1 = 0.8 时达到最高点。此外，溶解度值与温度呈正相关，这是固体溶质的典型特征。实验溶解度数据与一些著名的共溶模型相关联，并通过反向计算数据的平均相对偏差（MRDs%）来研究这些模型的准确性。范特霍夫模型的平均相对偏差为 1.2%，朱伊班-阿克里方程和朱伊班-阿克里-范特霍夫方程的平均相对偏差分别为 4.3% 和 4.6%，MRS 模型的平均相对偏差为 1.4%，修正的威尔逊模型的平均相对偏差为 2.1%。在 Thm = 303.0 K 条件下，还利用范特霍夫方程和吉布斯方程计算了 ADB 在非水饱和混合物中溶解的表观热力学参数（标准状态吉布斯能、焓和熵）。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.