Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airways diseases in the UK: a multicentre, longitudinal cohort study (PHOSP-COVID)
O. Elneima, John R Hurst, C. Echevarria, J. Quint, S. Walker, Salman Siddiqui, Petr Novotný, P. Pfeffer, Jeremy S Brown, M. Shankar-Hari, H. McAuley, O. Leavy, A. Shikotra, A. Singapuri, M. Sereno, Matthew Richardson, R. Saunders, V. C. Harris, L. Houchen-Wolloff, Neil J Greening, Ewen M Harrison, A. Docherty, Nazir I Lone, James D Chalmers, Ling-Pei Ho, Alexander Horsley, Michael Marks, K. Poinasamy, Betty Raman, Rachael A Evans, L. Wain, A. Sheikh, Chris E Brightling, A. De Soyza, L. Heaney
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引用次数: 0
Abstract
The long-term outcomes of COVID-19 hospitalisation in individuals with pre-existing airways diseases are unknown.Adult participants hospitalised for confirmed or clinically suspected COVID-19 and discharged between 5 March 2020 and 31 March 2021 were recruited to the Post-hospitalisation COVID-19 (PHOSP-COVID) study. Participants attended research visits at five-months and one-year post discharge. Clinical characteristics, perceived recovery, burden of symptoms and health related quality of life (HRQoL) of individuals with pre-existing airways disease (i.e., asthma, chronic obstructive pulmonary disease (COPD) or bronchiectasis) were compared to the non-airways group.A total of 615/2697 (22.8%) participants had a history of pre-existing airways diseases (72.0% diagnosed with asthma, 22.9% COPD and 5.1% bronchiectasis). At one-year, the airways group participants were less likely to feel fully recovered (20.4%versus33.2%, p<0.001), had higher burden of anxiety (29.1%versus22.0%, p=0.002), depression (31.2%versus24.7%, p=0.006), higher percentage of impaired mobility using Short Physical Performance Battery ≤10 (57.4%versus45.2%, p<0.001) and 27% had a new disability (assessed by the Washington Group Short Set on Functioning)versus16.6%, p=0.014. HRQoL assessed using EQ-5D-5 L Utility Index was lower in the airways group (0.64 (sd0.27)versus0.73 (sd0.25), p<0.001). Burden of breathlessness, fatigue and cough measured using a study specific tool was higher in the airways group.Individuals with pre-existing airways diseases hospitalised due to COVID-19 were less likely to feel fully recovered, had lower physiological performance measurements, more burden of symptoms and reduced HRQoL up to one-year post hospital discharge.
期刊介绍:
ERJ Open Research is a fully open access original research journal, published online by the European Respiratory Society. The journal aims to publish high-quality work in all fields of respiratory science and medicine, covering basic science, clinical translational science and clinical medicine. The journal was created to help fulfil the ERS objective to disseminate scientific and educational material to its members and to the medical community, but also to provide researchers with an affordable open access specialty journal in which to publish their work.