Median Canaliform Dystrophy of Heller in a Carpet Weaver: A New Risk Factor? – A Case Report

IF 17.7 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-03-28 DOI:10.1159/000538185
F. Z. El Fatoiki, A. El Kissouni, Soumiya Chiheb
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Abstract

Introduction: Median canaliform dystrophy of Heller (MCDH) is a rare nail disorder that typically affects the thumbnails and is characterized by transverse ridges radiating from a paramedian canal or split in the nail plate, bearing resemblance to a fir tree. Case Report: We report here a case of a 60-year-old woman of rural origin, a carpet weaver, with no specific medical history. She was referred due to nail dystrophy on her thumbs that had been progressing over the last 10 years. Clinical examination revealed the presence of a midline splitting with a fir tree-like appearance of ridges angled backwards and normal cuticle. These lesions were symmetrically present on both thumbnails and the big toe nail. Based on this presentation, a diagnosis of Heller's canaliform dystrophy was established. Conclusion: Although the pathophysiology of MCDH remains unclear, proposed mechanisms include keratinocyte adhesion abnormalities, genetic predisposition, and inflammation within the nail matrix. Risk factors encompass medications like oral retinoids and self-inflicted trauma, as seen in repetitive cuticle manipulation. In this case, the patient’s nail dystrophy resulted from chronic local microtrauma due to her carpet weaving occupation, suggesting certain manual professions may contribute to MCDH development.
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一名地毯织工的海勒中线管状营养不良症:新的风险因素?- 病例报告
简介海勒氏正中管状营养不良症(MCDH)是一种罕见的指甲疾病,通常会影响拇指指甲,其特征是从甲板的正中管或裂口处放射出的横脊,酷似一棵杉树。病例报告:我们在此报告一例 60 岁的农村妇女,她是一名地毯编织工,没有特殊病史。她因拇指甲营养不良而被转诊,该病在过去 10 年中一直在发展。临床检查发现,她的拇指中线出现劈裂,甲脊向后倾斜,呈杉树状,角质层正常。这些病变对称出现在两个拇指指甲和大脚趾甲上。根据这种表现,海勒管状营养不良症的诊断得以确立。结论虽然 MCDH 的病理生理学尚不清楚,但提出的机制包括角质细胞粘附异常、遗传易感性和甲基质内的炎症。风险因素包括口服维甲酸等药物和自身造成的创伤,如反复操作角质层。在本病例中,患者的甲营养不良症是由于她从事地毯编织工作造成的慢性局部微创伤引起的,这表明某些手工职业可能会导致甲营养不良症的发生。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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