Exploration of the cross-immunity between SARS-CoV and SARS-CoV-2 in mice

IF 2.1 4区 医学 Q3 VIROLOGY Future Virology Pub Date : 2024-03-26 DOI:10.2217/fvl-2023-0212
Shuhui Wang, Li Ren, Ying Liu, Xiuli Shen, Yanling Hao, Yiming Shao
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Abstract

Aim: This study aimed to develop a universal vaccine that can effectively address future outbreaks of coronavirus infections. Materials & methods: We developed recombinant DNA vaccines and vaccinia vector vaccines specific for SARS-CoV and SARS-CoV-2 and evaluated them in BALB/c mice. Both cellular and humoral immune responses were analyzed. Results: Compared with those immunized with the SARS-CoV or SARS-CoV-2 vaccine alone, the cross-immune group exhibited a 21.2-fold increase in cellular immune response, an over 80-fold increase in binding antibodies and a 136.7-fold increase in neutralizing antibodies. The combination of recombinant DNA and vaccinia vaccines induced a stronger immune response than DNA vaccine immunization alone. Conclusion: This study demonstrated that cross-immunization with different coronaviruses can induce a broad immune response.
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探索小鼠体内 SARS-CoV 和 SARS-CoV-2 的交叉免疫性
目的:本研究旨在开发一种通用疫苗,以有效应对未来冠状病毒感染的爆发。材料与方法:我们开发了针对 SARS-CoV 和 SARS-CoV-2 的重组 DNA 疫苗和疫苗载体疫苗,并在 BALB/c 小鼠中进行了评估。对细胞和体液免疫反应进行了分析。结果显示与单独免疫 SARS-CoV 或 SARS-CoV-2 疫苗的小鼠相比,交叉免疫组的细胞免疫反应增加了 21.2 倍,结合抗体增加了 80 多倍,中和抗体增加了 136.7 倍。与单独接种 DNA 疫苗相比,联合接种重组 DNA 和疫苗可诱导更强的免疫反应。结论这项研究表明,不同冠状病毒的交叉免疫可诱导广泛的免疫反应。
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来源期刊
Future Virology
Future Virology 医学-病毒学
CiteScore
4.00
自引率
3.20%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.
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