Antigenotoxic and Lifespan-Promoting Effects of Flavoured Kombuchas on Drosophila melanogaster

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-03-26 DOI:10.17113/ftb.62.02.24.8308

Ayşen Yağmur Burgazlı, Ghada Tagorti, B. Yalçın, Merve Güneş, Berfin Eroğlu, Eda Delik, Burcu Emine Tefon Öztürk, Bülent Kaya

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Abstract

Research background. Kombucha is a fermented beverage with several health benefits; however, to improve its antioxidant activity, new raw materials consisting of hop, madimak, and hawthorn were included in the present study. Experimental approach. The Drosophila Somatic Mutation and Recombination Test (SMART) was used to evaluate the antigenotoxic potential of black tea kombucha and three-flavoured kombuchas (hop, madimak, and hawthorn) against H2O2- and K2Cr2O7-induced genotoxicity. Furthermore, a lifespan assay was performed to assess the effects of kombuchas on Drosophila longevity. Results and conclusions. According to the results obtained from the SMART assay, hop-flavoured kombucha attenuated genotoxicity induced by H2O2, and madimak-flavoured kombucha reduced genotoxicity induced by H2O2 and K2Cr2O7. Black tea kombucha and hop-flavoured kombucha prolonged the lifespan of Drosophila after H2O2 and K2Cr2O7 exposure. Novelty and scientific contribution. Hop-flavoured kombucha is a promising antioxidant that protects the genome and extends the lifespan of Drosophila. This study sheds light on novel beverages that can combat aging and protect against genotoxicity.

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风味昆布对黑腹果蝇的抗原毒性和寿命促进作用

研究背景。昆布茶是一种具有多种保健功效的发酵饮料；然而，为了提高其抗氧化活性，本研究采用了由酒花、马迪马克和山楂组成的新原料。实验方法：采用果蝇体细胞突变和重组试验（SMART）来评估红茶昆布茶和三味昆布茶（酒花、马迪玛克和山楂）对 H2O2- 和 K2Cr2O7 诱导的基因毒性的抗原毒性潜力。此外，还进行了寿命测定，以评估昆布茶对果蝇寿命的影响。根据 SMART 试验得出的结果，酒花味昆布茶减轻了 H2O2 诱导的基因毒性，而马迪玛克味昆布茶减轻了 H2O2 和 K2Cr2O7 诱导的基因毒性。红茶昆布茶和酒花味昆布茶延长了果蝇在接触 H2O2 和 K2Cr2O7 后的寿命。酒花味昆布茶是一种很有前途的抗氧化剂，它能保护果蝇的基因组并延长其寿命。这项研究揭示了可抗衰老和防止基因毒性的新型饮料。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.