Development and validation of an analytical method for acetamiprid determination in plant protection products using HPLC-DAD

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-03-25 DOI:10.1556/1326.2024.01214

Patrycja Marczewska, Joanna Rolnik, T. Stobiecki, M. Sajewicz

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Abstract

Plant protection products (PPP), crucial for agricultural production, are experiencing increased global demand, particularly with the growing need for food production. To meet this demand, robust analytical methods are essential for confirming the presence and determining active substance concentrations in PPP. This study introduces an analytical method utilizing high-performance liquid chromatography with a diode array detector (HPLC-DAD) for determination of acetamiprid in water-soluble powder formulations. The method, validated according to SANCO/3030/99 rev.5, demonstrated exhibited adequate accuracy and precision, with repeatability expressed as the ratio of the standard deviation (% RSD) to the relative standard deviation (% RSDr) being lower than 1. Recoveries for the active substance at concentrations above 10% ranged from 97% to 103%. The developed method is also characterized by suitable linearity, confirmed by a correlation coefficient >0.99. Specific chromatographic profiles were generated, and acetamiprid content in 180 formulations was analyzed, including reference products. The developed method aligns with “green chemistry” principles, minimizing solvent use and emphasizing energy efficiency. Overall, it offers a comprehensive approach for qualitative and quantitative analysis, ensuring the reliability of PPP quality control.

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利用 HPLC-DAD 开发和验证测定植保产品中啶虫脒含量的分析方法

植保产品（PPP）对农业生产至关重要，全球对它的需求正在不断增加，特别是随着粮食生产需求的不断增长。为满足这一需求，必须采用可靠的分析方法来确认植保产品中活性物质的存在并确定其浓度。本研究介绍了一种利用高效液相色谱-二极管阵列检测器（HPLC-DAD）测定水溶性粉剂中啶虫脒含量的分析方法。该方法根据 SANCO/3030/99 rev.5 进行了验证，结果表明具有足够的准确度和精密度，用标准偏差（% RSD）与相对标准偏差（% RSDr）之比表示的重复性低于 1。浓度高于 10%时，活性物质的回收率为 97% 至 103%。所开发的方法还具有适当的线性特征，相关系数大于 0.99。生成了特定的色谱图，分析了 180 种制剂（包括参照产品）中的啶虫脒含量。所开发的方法符合 "绿色化学 "原则，最大限度地减少了溶剂的使用并强调了能源效率。总之，它为定性和定量分析提供了一种全面的方法，确保了 PPP 质量控制的可靠性。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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