Seroepidemiology of Toxoplasma gondii in diabetic patients type 2 by enzyme-linked immunosorbent assay method in Zabol City, 2017–2018

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-03-01 DOI:10.4103/jrms.jrms_49_23

M. Dabirzadeh, Mojtaba Sargazi, Somayeh Bagheri

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Abstract

Type 2 diabetes mellitus (T2DM) is prone to opportunistic infections, including toxoplasmosis, due to an immunodeficiency system. This study aimed to evaluate the serum of people with T2DM to determine the titer of anti-toxoplasma antibodies in patients and compare it with the control group. 720 blood samples have been carried out between October and the end of January 2017 in Sistan, and Baluchestan provinces in southeastern Iran, of these, 360 samples were related to healthy individuals (control), and 360 samples were related to T2DM individuals. The immunoglobulin (Ig) M and IgG enzyme-linked immunosorbent assay methods have been used to detect toxoplasmosis. The data were analyzed using SPSS-19, Chi-square, and Fisher’s exact test to compare statistical parameters. In this cross-sectional study, out of 360 samples of T2DM by ELISA method, 60% samples in diabetic patients and 48.1% in control group were IgG positive (P < 0.05). Nearly 2.5% samples in diabetic patients and 0.3% in control group were IgM positive (P < 0.05). Anti-toxoplasma antibodies including IgG and IgM were higher in diabetic patient in comparison to control group.

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2017-2018年扎布尔市2型糖尿病患者中用酶联免疫吸附法检测的弓形虫血清流行病学情况

2 型糖尿病（T2DM）患者由于免疫系统缺陷，很容易发生机会性感染，包括弓形虫病。本研究旨在对 T2DM 患者的血清进行评估，以确定患者体内抗弓形虫抗体的滴度，并与对照组进行比较。 2017 年 10 月至 1 月底期间，在伊朗东南部的锡斯坦省和俾路支斯坦省采集了 720 份血液样本，其中 360 份样本与健康人（对照组）有关，360 份样本与 T2DM 患者有关。采用免疫球蛋白 (Ig) M 和 IgG 酶联免疫吸附测定法检测弓形虫。数据采用 SPSS-19、Chi-square 和 Fisher's 精确检验进行分析，以比较统计参数。在这项横断面研究中，采用 ELISA 方法检测的 360 份 T2DM 样本中，糖尿病患者和对照组分别有 60% 和 48.1% 的样本 IgG 阳性（P < 0.05）。近 2.5%的糖尿病患者样本和 0.3%的对照组样本呈 IgM 阳性（P < 0.05）。与对照组相比，糖尿病患者的抗弓形虫抗体（包括 IgG 和 IgM）更高。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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