The role of the key endocannabinoids and their receptros in breast cancer

Abstract

Breast cancer is the main cause of death of women from cancer. Endocannabinoids and their exogenous analogues, for example, tetrahydrocannabinol, exhibit antitumor effect on a wide range of animal models of cancer. However, several studies have shown that under certain conditions, treatment with cannabinoids can stimulate the proliferation of cancer cells in vitro and disrupt the immune system's involvement in suppressing tumors. There are also conflicting reports about the antitumor role of the endocannabinoid system itself in cancer. The purpose of this review is to consider the main options for the action of key ligands and receptors of the endocannabinoid system in the context of breast cancer.