Assessment Of The Anti-Diabetic Activicty Of Schefflera Stellata Leaves Ethanolic Extract On Streptozotocin-Induced Diabetes In Wistar Rats

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels, affecting millions of people worldwide. This study aimed to evaluate the potential anti-diabetic activity of Schefflera stellata leaves ethanolic extract in a streptozotocin (STZ)-induced diabetic Wistar rat model. Wistar rats were induced with diabetes using STZ and subsequently treated with Schefflera stellata leaves ethanolic extract. Various biochemical parameters such as fasting blood glucose levels, serum insulin levels, lipid profile, and antioxidant enzyme activities were assessed. Additionally, histopathological examination of pancreatic tissues was performed to evaluate the impact of the extract on structural alterations. The results revealed a significant reduction in fasting blood glucose levels in rats treated with Schefflera stellata extract compared to the untreated diabetic group. Moreover, the extract exhibited a positive influence on serum insulin levels, lipid profile, and antioxidant enzyme activities, suggesting its potential in ameliorating diabetes-induced metabolic dysregulation. Histopathological analysis of pancreatic tissues indicated a preservation of islet architecture in the extract-treated group, highlighting the protective effects of Schefflera stellata against STZ-induced pancreatic damage.