Application of radiogenomics in head and neck cancer: A new tool toward diagnosis and therapy

Abstract

Head and neck cancer is a significant threat to human health and is characterized by high 5-year morbidity and mortality rates. Addressing this challenge requires the application of precision medicine, but the inherent heterogeneity of head and neck cancer complicates its treatment. Radiogenomics, an interdisciplinary field at the intersection of genomics and radiology, may represent a solution. Radiogenomics offers the potential to revolutionize the diagnosis and treatment of this complex and diverse disease. By comprehensively analyzing the genetic information and radiological features of tumors, clinicians can gain a profound understanding of patients' conditions. Gaining such in-depth insight facilitates early detection and implementation of personalized treatment strategies, both of which are integral components of precision medicine. Tailored treatments, including surgical interventions and targeted therapies, provide improved outcomes and reduced side effects. Radiogenomics represents a groundbreaking advancement that has the potential to significantly enhance the quality of care and outcomes of patients with head and neck cancer. To shed light on this transformative approach, we performed a comprehensive overview of radiomics and radiogenomics-based diagnostic methods tailored to the unique characteristics of head and neck cancer.