The Compatibility of Oxytocin and Tranexamic Acid Injection Products When Mixed for Coadministration by Infusion for the Treatment of Postpartum Hemorrhage: An In Vitro Investigation
P. Lambert, A. Tomazzini, P. Wright, C. McEvoy, I. Gallos, A. Ammerdorffer, L. Chinery, A. Coomarasamy, A.M. Gulmezoglu
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Abstract
(BJOG. 2023;130:741–749)
Postpartum hemorrhage (PPH) is defined as the loss of more than 1000 mL of blood after childbirth. Signs and symptoms are present after birth, and they can be prevented. The World Health Organization has defined treatment for PPH. World Health Organization has created a bundle of recommendations based on evidence consisting of uterotonic medications, tranexamic acid (TXA), intravenous fluids, and uterine massage. This treatment bundle is known as E-MOTIVE intervention and is to be administered in cases of PPH.
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