Expression patterns of eighteen genes involved in crucial cellular processes in the TP53 pathway in Multiple Myeloma

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-02-13 DOI:10.35378/gujs.1365179

G. Öztan, Ilknur Suer, Aynur Dağlar Aday, M. Ayer, Ş. Öztürk, K. Çefle, M. Yenerel, H. Issever, S. Palanduz

引用次数: 0

Abstract

Multiple myeloma (MM) is a cancerous disease that involves abnormal production of immunoglobulins by bone marrow plasma cells. The relationship between MM and the TP53 pathway has not been fully elucidated in the literature. Investigation of the effect of the expression of genes in the TP53 pathway on the molecular pathogenesis and prognosis of multiple myeloma disease. We assessed the expression of 18 genes in the TP53 pathway in 48 MM patients and 31 healthy subjects by RT2-profiler PCR array technique, and investigated their possible association with the presence of cytogenetic aberrations. Twelve of the 18 genes (APAF1, ATM, BAX, CASP9, CDK4, CDKN1A, CDKN2A, E2F1, MCL1, MDM2, MDM4, PTEN) expression levels were found to be statistically up-regulated in MM patients compared to controls. The CDK4, CDKN1A and MCL1 genes were found to have remarkable diagnostic power distinguishing MM and healthy controls (AUC=0.89;AUC=0.86;AUC=0.77, respectively and p

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多发性骨髓瘤中参与 TP53 通路关键细胞过程的 18 个基因的表达模式

多发性骨髓瘤（MM）是一种涉及骨髓浆细胞异常产生免疫球蛋白的癌症疾病。文献尚未完全阐明 MM 与 TP53 通路之间的关系。调查 TP53 通路中基因的表达对多发性骨髓瘤疾病的分子发病机制和预后的影响。我们通过RT2-profiler PCR阵列技术评估了48名MM患者和31名健康受试者中TP53通路中18个基因的表达，并研究了它们与细胞遗传学畸变存在的可能关联。结果发现，与对照组相比，18个基因中有12个（APAF1、ATM、BAX、CASP9、CDK4、CDKN1A、CDKN2A、E2F1、MCL1、MDM2、MDM4、PTEN）在MM患者中的表达水平呈统计学上调。研究发现，CDK4、CDKN1A 和 MCL1 基因在区分 MM 和健康对照组方面具有显著的诊断能力（AUC=0.89；AUC=0.86；AUC=0.77，分别为 0.89、0.86、0.77、0.77）。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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