{"title":"Overview of Leprosy Reactions at Universitas Sumatera Utara Medical Faculty Hospitals between 2017 and 2021","authors":"R. Lubis, Ariyati Yosi","doi":"10.3889/oamjms.2024.11837","DOIUrl":null,"url":null,"abstract":"BACKGROUND: Leprosy, or Morbus Hansen, is a chronic granulomatous disease caused by Mycobacterium leprae that involves the skin and peripheral nerves, with or without motor disorders. Leprosy reactions are immune-mediated acute or subacute inflammatory episodes that interfere with chronic disease and are classified into three types: type 1 (RR), type 2 (ENL), and the Lucio phenomenon.\nAIM: The purpose of the study is to describe the epidemiology of leprosy reactions at Universitas Sumatera Utara (USU) teaching hospitals and provide a description of factors associated with the reactions that might provide valuable information for future studies.\nMETHODS: This is a cross-sectional analytic study with total sampling on medical records of patients in the Dermatology and Venereology Polyclinic at H. Adam Malik Hospital Medan and USU Education Hospital in 2017–2021.\nRESULTS: The incidence of leprosy reactions at the USU Medical Faculty Education Hospital in 2017–2021 was 41 cases. The majority of reaction types were type 2 reactions (68.3%). Risk factors for type 1 reactions were a history of reactions, being elderly, multiple lesions or nerve involvement, and co-infections, whereas the risk factors for type 2 reactions were LL, younger age, bacterial index >4+, stress, and co-infections. The highest age group proportion was 18–59 years (95.1%) and was more common in men (70.7%), which mostly appeared before treatment (39.1%). The incidence of leprosy reactions was 26 new cases per 100 patients.\nCONCLUSION: The highest proportion of leprosy reactions was type 2, within the adult age group (18–59 years), males, and before treatment.","PeriodicalId":19562,"journal":{"name":"Open Access Macedonian Journal of Medical Sciences","volume":"278 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Access Macedonian Journal of Medical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3889/oamjms.2024.11837","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
BACKGROUND: Leprosy, or Morbus Hansen, is a chronic granulomatous disease caused by Mycobacterium leprae that involves the skin and peripheral nerves, with or without motor disorders. Leprosy reactions are immune-mediated acute or subacute inflammatory episodes that interfere with chronic disease and are classified into three types: type 1 (RR), type 2 (ENL), and the Lucio phenomenon.
AIM: The purpose of the study is to describe the epidemiology of leprosy reactions at Universitas Sumatera Utara (USU) teaching hospitals and provide a description of factors associated with the reactions that might provide valuable information for future studies.
METHODS: This is a cross-sectional analytic study with total sampling on medical records of patients in the Dermatology and Venereology Polyclinic at H. Adam Malik Hospital Medan and USU Education Hospital in 2017–2021.
RESULTS: The incidence of leprosy reactions at the USU Medical Faculty Education Hospital in 2017–2021 was 41 cases. The majority of reaction types were type 2 reactions (68.3%). Risk factors for type 1 reactions were a history of reactions, being elderly, multiple lesions or nerve involvement, and co-infections, whereas the risk factors for type 2 reactions were LL, younger age, bacterial index >4+, stress, and co-infections. The highest age group proportion was 18–59 years (95.1%) and was more common in men (70.7%), which mostly appeared before treatment (39.1%). The incidence of leprosy reactions was 26 new cases per 100 patients.
CONCLUSION: The highest proportion of leprosy reactions was type 2, within the adult age group (18–59 years), males, and before treatment.
期刊介绍:
Open Access Macedonian Journal of Medical Sciences (OAMJMS) [formerly known as Macedonian Journal of Medical Sciences] is a top-tier open access medical science journal published by the ID Design 2012/DOOEL Skopje, Rajko Zhinzifov No 48, 1000 Skopje, Republic of Macedonia. OAMJMS is an international, modern, general medical journal covering all areas in the medical sciences, from basic studies to large clinical trials and cost-effectiveness analyses. We publish mostly human studies that substantially enhance our understanding of disease epidemiology, etiology, and physiology; the development of prognostic and diagnostic technologies; trials that test the efficacy of specific interventions and those that compare different treatments; and systematic reviews. We aim to promote translation of basic research into clinical investigation, and of clinical evidence into practice. We publish occasional studies in animal models when they report outstanding research findings that are highly clinically relevant. Our audience is the international medical community as well as educators, policy makers, patient advocacy groups, and interested members of the public around the world. OAMJMS is published quarterly online version. The Open Access Macedonian Journal of Medical Sciences (OAMJMS) publishes Medical Informatics, Basic Science, Clinical Science, Case Report, Brief Communication, Public Health, Public Policy, and Review Article from all fields of medicine and related fields. This journal also publishes, continuously or occasionally, the bibliographies of the members of the Society, medical history, medical publications, thesis abstracts, book reviews, reports on meetings, information on future meetings, important events and dates, and various headings which contribute to the development of the corresponding scientific field.