ANTIBACTERIAL PROPERTIES OF ORGANOTELLURIUM COMPOUNDS

Abstract

Introduction. Antimicrobial resistance in bacteria has become a global challenge for public health systems. Bacteria that pose the greatest threat to human health due to their increasing resistance to antibiotics include Escherichia coli, Staphylococcus aureus and Salmonella spp. The purpose of the work is to study the antibacterial properties of three tellurium derivatives against infections caused by Staphylococcus, Escherichia coli and Salmonella. Material and methods. The object of study is heterocyclic tellurium derivatives. A comparative analysis of the antibacterial properties of the syn-thesized tellurium derivatives on bacterial strains of Staphylococcus, Escherichia coli and Salmonella was carried out. To determine the antibacterial properties, the serial dilution method was used. The sensitivity of bacteria to the test tellurium derivatives and to antibiotics was assessed using the disk- diffusion method. Results. The study of three tellurium derivatives in different concentrations made it possible to determine the minimum inhibitory concentration (MIC) for organotellurium compounds, which were 1.35, 0.12 and 0.2 μg of the substance per 1 disk, respectively. For dioxysirocyclo-[4-methylphenyl] tellu-rochloride against E. coli and S. aureus, the minimum inhibitory concentrations (MIC50) were determined to be 16.4 and 18.6 μg of the substance per 1 disk, respectively. Conclusions. The effect of organotellurium substances in relatively low concentrations on strains of bacteria Staphylococcus, Escherichia coli and Salmonella indicates the prospects for further study of the biological properties of tellurium derivatives containing various groups.