A Review on the Role of Neuroplasticity in Neurodegenerative Disorders and Its Possible Pharmacological and Non-Pharmacological Interventions

Rana Muhammad Nabeel Aslam, Noor-ul-Ain, Husnain Ali, Ayesha Muzammil, Anam Iqbal
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Abstract

Neuroplasticity is the capability of brain cells to interchange as well as modify for the ultimate cause of higher proficiency to acclimatize to the new situations. Neuroplasticity also plays a very pivotal role in the development and then further progressing of neurodegenerative disorders. The severe adjustments in neural plasticity caused by high pressure, anxiety and other terrible stimuli like stress play a considerable role in the onset and cause of depression. This comprehensive review explores the pivotal role of neuroplasticity in neurodegenerative disorders, shedding light on the dynamic adaptive processes of the nervous system in response to pathological conditions. The paper synthesizes current research findings to elucidate the intricate interplay between neuroplasticity and the progression of neurodegenerative diseases. Furthermore, it delves into potential pharmacological and non-pharmacological interventions aimed at modulating neuroplasticity to ameliorate or mitigate the impact of these disorders. By examining diverse strategies, from pharmaceutical interventions to lifestyle modifications, this review contributes to a nuanced understanding of the multifaceted mechanisms underlying neurodegeneration and offers insights into promising avenues for therapeutic development.
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神经可塑性在神经退行性疾病中的作用及其可能的药物和非药物干预综述
神经可塑性是指脑细胞为了更熟练地适应新环境而进行互换和修改的能力。神经可塑性在神经退行性疾病的发展和进一步恶化中也起着非常关键的作用。高压、焦虑和其他可怕的刺激(如压力)导致的神经可塑性的严重调整在抑郁症的发病和成因中起着相当大的作用。这篇综述探讨了神经可塑性在神经退行性疾病中的关键作用,揭示了神经系统在病理条件下的动态适应过程。论文综合了当前的研究成果,阐明了神经可塑性与神经退行性疾病进展之间错综复杂的相互作用。此外,论文还深入探讨了旨在调节神经可塑性的潜在药物和非药物干预措施,以改善或减轻这些疾病的影响。通过研究从药物干预到生活方式调整的各种策略,这篇综述有助于深入了解神经退行性疾病的多方面机制,并为有前景的治疗开发途径提供见解。
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