Toxic epidermal necrolysis induced by COVID-19

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-01-30 DOI:10.4081/dr.2024.9853
Duaa Alahmadi, Azhar Ahmed, Walaa Borhan, Ahmad Ozbuck, Esraa Shaheen
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Abstract

Toxic epidermal necrolysis (TEN) is a life-threatening acute mucocutaneous syndrome. It is characterized by keratinocyte necrosis and apoptosis, which affect more than 30% of the body's surface. TEN is most commonly due to an altered immunological response to specific drugs, infections, and malignancies, or it can be idiopathic. The combination of TEN and COVID-19 can have a fatal outcome if not recognized and promptly treated. Therefore, fast reporting of such cases will draw doctors’ attention to quick and right intervention. In this article, we present a 66-year-old patient with a clinical presentation of toxic epidermal necrolysis along with a coexisting COVID-19 infection. To our knowledge, this is the first case of TEN in a patient diagnosed with SARS CoV‑2 infection in Saudi Arabia.
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COVID-19 诱导的中毒性表皮坏死症
中毒性表皮坏死(TEN)是一种危及生命的急性皮肤粘膜综合征。它以角质细胞坏死和凋亡为特征,影响人体表面 30% 以上的皮肤。TEN 最常见的原因是对特定药物、感染和恶性肿瘤的免疫反应发生改变,也可能是特发性的。如果不及时发现和治疗,TEN 和 COVID-19 的合并症可能会导致致命的后果。因此,快速报告此类病例将引起医生的注意,以便进行快速、正确的干预。在本文中,我们介绍了一名临床表现为中毒性表皮坏死同时合并 COVID-19 感染的 66 岁患者。据我们所知,这是沙特阿拉伯首例确诊为 SARS CoV-2 感染的 TEN 患者。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
期刊介绍: ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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