Serum levels of neuregulin-1 in patients with coronary artery disease: clinical and pathogenetic aspects

Q3 Social Sciences Cardiovascular Therapy and Prevention Pub Date : 2024-01-29 DOI:10.15829/1728-8800-2024-3776

E. A. Zakharyan, A. Ushakov

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Abstract

Aim. To determine the relationship between the serum level of neu-regulin-1 (NRG-1) and the severity of coronary artery (CA) atherosclerosis and clinical and paraclinical characteristics of patients with coronary artery disease (CAD).Material and methods. The study included 264 people, of which 220 were patients diagnosed with coronary CAD. The patients underwent coronary angiography using the Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery (SYNTAX) score and echocardiography. The patients were divided into groups according to SYNTAX score: group 1 — with moderate CA atherosclerosis (≤22 (n=124); group 2 — with severe CA atherosclerosis (23-32) (n=53); group 3 — with extremely severe CA atherosclerosis (≥33) (n=43). Group 4 was represented by healthy volunteers (n=44). All subjects underwent a study of the serum NRG-1 (ng/ml) level. Statistical processing of the results was carried out using Statistica 10.0 software. Differences were considered significant at p<0,05.Results. Significantly higher NRG-1 values were obtained in the control group compared to patients with CAD (p<0,001). An inverse correlation was found between the NRG-1 concentration and the severity of CA atherosclerosis (p<0,001). A decrease in NRG-1 concentration is associated with a high functional class of = heart failure (p<0,01) and low left ventricular ejection fraction (p<0,001). The significance of NRG-1 differences between groups of patients with a history of myocardial infarction (p<0,001), angina pectoris (p<0,01), permanent atrial fibrillation (p<0,01), chronic left ventricular aneurysm (p<0,01) and repeated myocardial infarction (p<0,05) in comparison with patients without these pathologies.Conclusion. The identified correlations between the NRG-1 concentration and CAD, as well as the clinical and paraclinical characteristics of patients, makes it possible to consider NRG-1 as a reliable biomarker of CA and heart failure severity and may form the basis for the development of novel diagnostic approaches.

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冠心病患者血清中的神经胶质蛋白-1水平：临床和病理方面的问题

目的研究冠状动脉疾病（CAD）患者血清中神经调节素-1（NRG-1）水平与冠状动脉（CA）粥样硬化严重程度以及临床和辅助临床特征之间的关系。研究共纳入 264 人，其中 220 人为确诊为冠状动脉粥样硬化的患者。这些患者使用 TAXUS 经皮冠状动脉介入治疗和心脏手术协同作用（SYNTAX）评分和超声心动图进行了冠状动脉造影。根据SYNTAX评分将患者分为以下几组：第1组--中度CA动脉粥样硬化（≤22（n=124））；第2组--重度CA动脉粥样硬化（23-32）（n=53）；第3组--极重度CA动脉粥样硬化（≥33）（n=43）。第 4 组为健康志愿者（人数=44）。所有受试者都接受了血清 NRG-1 （纳克/毫升）水平研究。使用 Statistica 10.0 软件对结果进行统计处理。P<0.05为差异显著。对照组的 NRG-1 值明显高于 CAD 患者（P<0,001）。NRG-1浓度与CA动脉粥样硬化的严重程度呈负相关（p<0,001）。NRG-1浓度的降低与高功能分级=心衰（p<0,01）和低左室射血分数（p<0,001）有关。有心肌梗塞病史（p<0,001）、心绞痛（p<0,01）、永久性心房颤动（p<0,01）、慢性左心室动脉瘤（p<0,01）和反复心肌梗塞（p<0,05）的患者组与无这些病史的患者组之间的NRG-1差异显著。NRG-1浓度与CAD以及患者的临床和辅助临床特征之间的相关性使我们有可能将NRG-1视为CA和心衰严重程度的可靠生物标志物，并为开发新型诊断方法奠定基础。

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来源期刊

Cardiovascular Therapy and Prevention Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.70

自引率

0.00%

发文量

155

审稿时长

6-12 weeks

期刊介绍： The most important objectives of the journal are: the generalization of scientific and practical achievements in the field of cardiology, increasing scientific and practical skills of cardiologists. The scientific concept of publication does the publication of modern achievements in the field of epidemiology, prevention and treatment of cardiovascular diseases, the results of research, national and international clinical trials. For publication in the journal are invited both domestic and foreign scientists and clinicians working in the field of cardiology, as well as doctors of other specialties. The magazine covers various issues in cardiology and related specialties. Each issue is prepared by Executive editor of the issue, a respected specialist in the field of epidemiology, prevention and treatment of cardiovascular diseases. The main focus of the publication — scientific articles on original research, the pharmacotherapy of cardiovascular disease, new diagnostic methods. All members of the group of authors should meet all four criteria of authorship set forth in the ICMJE recommendations: 1) concept and design development or data analysis and interpretation, and 2) manuscript justification or verification of critical intellectual content, and 3) final approval for publication of the manuscript, and 4) consent to be responsible for all aspects of the work, and assume that issues relating to the thoroughness and diligent execution of any part of the study submitted are duly investigated and resolved. Great importance the editors attached to the preparation of scientific papers by groups of authors at a high level, literacy, authors, and their ownership information, availability of research results not only to colleagues in Russia, but also abroad.