Diagnostic importance of P16 in the differential diagnosis of well-differentiated liposarcoma and lipomas

IF 1.1 Q4 IMMUNOLOGY Immunopathologia Persa Pub Date : 2024-01-29 DOI:10.34172/ipp.2023.40558

P. Hedayat, M. Derakhshan, Laya Golshani, Arash Hedayat

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Abstract

Introduction: Because of pathological overlaps, distinguishing well-differentiated liposarcoma (WDL) from lipoma is difficult. Objectives: The purpose of this study was to evaluate P16 as a differentiating marker for WDL and lipomas Materials and Methods: This cross-sectional study was performed on 38 pathology samples of lipoma and WDL in the department of pathology of Al-Zahra hospital, affiliated with Isfahan university of medical sciences, from 2011 to 2018. The studied samples were examined by immunohistochemistry (IHC) to determine the presence of P16. Results: Evaluation of IHC data showed that all of the lipoma samples (100%) had a score of 0 for IHC staining. In comparison, 84.2% of liposarcoma samples had a score of 3, and this difference was statistically significant (P<0.001). Evaluating the sensitivity and specificity of P16 gene expression showed that this marker has 84% sensitivity and 100% specificity for diagnosing liposarcoma (95% CI: 0.6042-0.9661). Conclusion: The use of p16 to differentiate WDL from lipoma has a sensitivity of 84% and a specificity of 100%, which could be very helpful in pathological practice.

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P16 在鉴别诊断分化良好的脂肪肉瘤和脂肪瘤中的诊断重要性

导言：由于病理重叠，很难将分化良好的脂肪肉瘤（WDL）与脂肪瘤区分开来。研究目的本研究旨在评估 P16 作为区分 WDL 和脂肪瘤的标志物的作用：本横断面研究于 2011 年至 2018 年期间在伊斯法罕医科大学附属扎赫拉医院病理科对 38 份脂肪瘤和 WDL 的病理样本进行了研究。研究样本通过免疫组化（IHC）检测P16的存在。结果显示IHC 数据评估显示，所有脂肪瘤样本（100%）的 IHC 染色得分均为 0。相比之下，84.2%的脂肪肉瘤样本的 IHC 得分为 3，这一差异具有统计学意义（P<0.001）。对 P16 基因表达的敏感性和特异性进行评估后发现，该标记物对脂肪肉瘤诊断的敏感性为 84%，特异性为 100%（95% CI：0.6042-0.9661）。结论使用P16来区分WDL和脂肪瘤的敏感性为84%，特异性为100%，这对病理实践很有帮助。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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