Evaluation of Bone Microstructure Parameters by Using Tomographic Methods and Compressive Strength Estimation

Abstract

Objective: The aim of this study was to evaluate the microstructure of the mandible by micro computed tomography (µCT), cone beam computed tomography (CBCT) and computed tomography (CT) and to estimate the compressive strength of the bone based on the values obtained by these methods. Methods: Thirty specimens obtained from ex-vivo sheep mandible were scanned by µCT cone beam computed tomography and computed tomography. These specimens were also subjected to compression testing and compression strength values were calculated. Morphometric parameters were evaluated using ImageJ software Bland-Altman lower upper bound agreement and ICC coefficient were used to evaluate the agreement between the tomography methods used and the gold standard. Linear and multivariate stepwise regression analysis was performed to calculate the compression strength value based on the radiomorphometric parameters. Statistical significance level was accepted as .05. Results: Bone Surface/Total Volume, Bone Volume/Total Volume and Degree of Anistoropy parameters evaluated by CBCT and Fractal Dimension parameter evaluated by CT showed a statistically significant agreement with the gold standard method µCT. Bone Volume/Total Volume and Degree of Anistoropy parameters obtained with µCT (R2:0.75), Bone Volume/Total Volume, Degree of Anistoropy , Connectivity Density parameters (R2:0.62), and the Structure Model Index parameter (R2:0.13) obtained by CT can be used to predict the compression strength value. Conclusion: Bone compression strength can be estimated by CBCT and µCT methods in a desired level. Bone Volume/Total Volume and Degree of Anistoropy parameters are significant determinants of bone mechanical property in not only µCT but also CBCT method.