Abstracts of “Institute for Research and Medical Consultations (IRMC) - Summer Research Program - 2023” presented at Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, on August 28, 2023

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-01-15 DOI:10.4103/sjmms.SJMMS_40_24

Hussain Anwar Alkatheri, N. Almandil, Rahaf Alquwaie, Razan Aldahhan, Norah F Alhur, Reem AlJindan, S. Abdulazeez, J. Borgio, Shikhah Abdullah Alomran, N. Qahtani, Fahd M AlShehri, Zahra Alsafwani, Esra Ahdal, Adel S. Almutairi, S. Almofty, J. Borgio, Dalal Mohammed‑Akram, Motabagani, Eman AlHasani, Showq H. Alshammery, Lujeen H. Alghourab, Norah Fahad Alamri, Wojod Alothman, Mohammad H. Albakhit, Amani A. AlHejji, Faisal Mohammed Alanazi, B. R. Jermy, Mohammad Azam Ansari, Fatimah Zuhair Alabdrabalnabi, Muhammad Nawaz, F. A. Khan, Sultan Akhtar, Kawther Altalaq, Shoug Saleh Alhbabi, D. Almohazey, Thamer Alshammari, M. Almessiere

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Abstract

Background: Fetal nucleated red blood cells (fNRBCs) are cells of fetal origin and are present in maternal peripheral blood during pregnancy. fNRBCs have distinctive morphological features as they have a diameter of 9 to 13 µ m, an intact and dense nucleus and a low nucleus-to-cytoplasm ratio. Researchers proposed the use of fNRBCs as a non-invasive prenatal testing (NIPT) alternative to invasive procedures such as amniocentesis or chorionic villus sampling. The full genome of the fetus is encapsulated within fNRBCs, enabling the detection of genetic variations. However, the primary challenge lies in the scarcity of the fNRBCs, and limited number of biomarkers that differ from the maternal cells. Objective: The study aims to use live cell imaging to identify fNRBC’s unique characteristics in the maternal blood during pregnancy. Methods: The samples from pregnant mothers at full term were collected in EDTA vacutainers from the obstetrics and gynecology clinics at KFUH. Informed consent was obtained from all participants. The double-density

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2023 年 8 月 28 日在沙特阿拉伯达曼伊玛目阿卜杜勒拉赫曼-本-费萨尔大学举办的 "研究与医疗咨询研究所（IRMC）--2023 年暑期研究计划 "的摘要

背景：胎儿有核红细胞（fNRBCs）是来源于胎儿的细胞，在怀孕期间存在于母体外周血中。fNRBCs具有独特的形态特征，其直径为9至13微米，细胞核完整致密，核浆比低。研究人员建议使用 fNRBC 作为无创产前检测（NIPT）的替代方法，以取代羊膜腔穿刺术或绒毛取样等有创程序。胎儿的全基因组被封装在 fNRBC 中，从而能够检测基因变异。然而，主要的挑战在于 fNRBC 的稀缺性，以及与母体细胞不同的生物标志物数量有限。研究目的本研究旨在利用活细胞成像技术识别孕期母体血液中 fNRBC 的独特特征。研究方法在 KFUH 的妇产科诊所收集足月孕妇的 EDTA 真空采血管样本。所有参与者均已知情同意。双密度

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.