Eradication of Helicobacter pylori: a prospective comparative randomized trial of standard versus optimized quadruple therapy

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-01-01 DOI:10.2144/fsoa-2023-0316

Salma Souissi, Cyrine Makni, Basma Chaieb, Amine Jarraya, Nadia Toulgui, L. Jmal, Mouna Mlika, Chadlia Fendri, Mohamed Bouchoucha, R. Razgallah, Leila Belhadj Ammar, O. Bousnina, Fawzi Mezni, Awatef Jmal, Lamia Kallel

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Abstract

The treatment of Helicobacter pylori infection remains a challenge. None of the proposed treatment regimens has resulted in a 100% eradication rate. The aim of our study was to compare the rate of H. pylori eradication after standard or dose-optimized amoxicillin quadruple therapy. We conducted a prospective comparative study collating patients naive to any anti- H. pylori treatment and with chronic H. pylori infection documented by histological examination. Patients were randomly assigned to either standard quadruple therapy or optimized quadruple therapy. Eradication control was performed by urea breath test. Eighty-eight eligible patients were included with 44 in each group.There was no significant difference between the eradication rates of Qo-14 and Qs-14 neither in ITT (84 vs 70.4%; p = 0.127) nor in PP (82.1 vs 77.7%; p = 0.473). Compliance and tolerance appeared similar in each group.

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根除幽门螺杆菌：标准四联疗法与优化四联疗法的前瞻性比较随机试验

幽门螺旋杆菌感染的治疗仍然是一项挑战。目前所提出的治疗方案中还没有一种能达到 100% 的根除率。我们的研究旨在比较标准或剂量优化阿莫西林四联疗法的幽门螺杆菌根除率。我们进行了一项前瞻性比较研究，研究对象是未接受过任何幽门螺杆菌抗生素治疗的患者，以及经组织学检查证实患有慢性幽门螺杆菌感染的患者。患者被随机分配接受标准四联疗法或优化四联疗法。根除控制通过尿素呼气试验进行。在 ITT（84 vs 70.4%；P = 0.127）和 PP（82.1 vs 77.7%；P = 0.473）中，Qo-14 和 Qs-14 的根除率均无显著差异。各组的依从性和耐受性相似。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.