Associations of behavioral problems with white matter circuits connecting to the frontal lobes in school-aged children born at term and preterm

Q4 Neuroscience Neuroimage. Reports Pub Date : 2024-04-12 DOI:10.1016/j.ynirp.2024.100201
Machiko Hosoki , Margarita Alethea Eidsness , Lisa Bruckert, Katherine E. Travis, Heidi M. Feldman
{"title":"Associations of behavioral problems with white matter circuits connecting to the frontal lobes in school-aged children born at term and preterm","authors":"Machiko Hosoki ,&nbsp;Margarita Alethea Eidsness ,&nbsp;Lisa Bruckert,&nbsp;Katherine E. Travis,&nbsp;Heidi M. Feldman","doi":"10.1016/j.ynirp.2024.100201","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>This study investigated whether internalizing and externalizing behavioral problems in children were associated with fractional anisotropy of white matter tracts connecting other brain regions to the frontal lobes. We contrasted patterns of association between children born at term (FT) and very preterm (PT: gestational age at birth =&lt; 32 weeks).</p></div><div><h3>Methods</h3><p>Parents completed the Child Behavior Checklist/6–18 questionnaire to quantify behavioral problems when their children were age 8 years (N = 36 FT and 37 PT). Diffusion magnetic resonance scans were collected at the same age and analyzed using probabilistic tractography. Multiple linear regressions investigated the strength of association between age-adjusted T-scores of internalizing and externalizing problems and mean fractional anisotropy (mean-FA) of right and left uncinate, arcuate, anterior thalamic radiations, and dorsal cingulate bundle, controlling for birth group and sex.</p></div><div><h3>Results</h3><p>Models predicting internalizing T-scores found significant group-by-tract interactions for left and right arcuate and right uncinate. Internalizing scores were negatively associated with mean-FA of left and right arcuate only in FT children (<em>p</em><sub>left AF</sub> = 0.01, <em>p</em><sub>right AF</sub> = 0.01). Models predicting externalizing T-scores found significant group-by-tract interactions for the left arcuate and right uncinate. Externalizing scores were negatively associated with mean-FA of right uncinate in FT (<em>p</em><sub>right UF</sub> = 0.01) and positively associated in PT children (<em>p</em><sub>right UF preterm</sub> = 0.01). Other models were not significant.</p></div><div><h3>Conclusions</h3><p>In children with a full range of scores on behavioral problems from normal to significantly elevated, internalizing and externalizing behavioral problems were negatively associated with mean-FA of white matter tracts connecting to frontal lobes in FT children; externalizing behavioral problems were positively associated with mean-FA of the right uncinate in PT children. The different associations by birth group suggest that the neurobiology of behavioral problems differs in the two birth groups.</p></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666956024000072/pdfft?md5=136e94ecc416ff2b192b7f32e54a59a0&pid=1-s2.0-S2666956024000072-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroimage. Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666956024000072","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Neuroscience","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction

This study investigated whether internalizing and externalizing behavioral problems in children were associated with fractional anisotropy of white matter tracts connecting other brain regions to the frontal lobes. We contrasted patterns of association between children born at term (FT) and very preterm (PT: gestational age at birth =< 32 weeks).

Methods

Parents completed the Child Behavior Checklist/6–18 questionnaire to quantify behavioral problems when their children were age 8 years (N = 36 FT and 37 PT). Diffusion magnetic resonance scans were collected at the same age and analyzed using probabilistic tractography. Multiple linear regressions investigated the strength of association between age-adjusted T-scores of internalizing and externalizing problems and mean fractional anisotropy (mean-FA) of right and left uncinate, arcuate, anterior thalamic radiations, and dorsal cingulate bundle, controlling for birth group and sex.

Results

Models predicting internalizing T-scores found significant group-by-tract interactions for left and right arcuate and right uncinate. Internalizing scores were negatively associated with mean-FA of left and right arcuate only in FT children (pleft AF = 0.01, pright AF = 0.01). Models predicting externalizing T-scores found significant group-by-tract interactions for the left arcuate and right uncinate. Externalizing scores were negatively associated with mean-FA of right uncinate in FT (pright UF = 0.01) and positively associated in PT children (pright UF preterm = 0.01). Other models were not significant.

Conclusions

In children with a full range of scores on behavioral problems from normal to significantly elevated, internalizing and externalizing behavioral problems were negatively associated with mean-FA of white matter tracts connecting to frontal lobes in FT children; externalizing behavioral problems were positively associated with mean-FA of the right uncinate in PT children. The different associations by birth group suggest that the neurobiology of behavioral problems differs in the two birth groups.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
学龄期足月儿和早产儿的行为问题与连接额叶的白质回路之间的关系
简介:本研究探讨了儿童的内化和外化行为问题是否与连接其他脑区和额叶的白质束的分数各向异性有关。我们对比了足月儿(FT)和极早产儿(PT:出生时胎龄=< 32周)之间的关联模式。方法 家长填写儿童行为检查表/6-18问卷,以量化孩子8岁时的行为问题(N = 36 FT和37 PT)。在同一年龄段收集了弥散磁共振扫描结果,并使用概率束学方法进行了分析。多重线性回归研究了年龄调整后的内化和外化问题T分值与左右钩状束、弓状束、丘脑前放射束和扣带回背束的平均分数各向异性(mean-FA)之间的关联强度,并对出生组别和性别进行了控制。只有 FT 儿童的内化得分与左右弓状体的平均-FA 负相关(pleft AF = 0.01,pright AF = 0.01)。预测外化 T 分值的模型发现,左侧弓状肌和右侧钩状肌具有显著的组间交互作用。FT儿童的外部化得分与右弓状肌的平均FA呈负相关(pright UF = 0.01),而PT儿童的外部化得分与右弓状肌的平均FA呈正相关(pright UF preterm = 0.01)。结论 在行为问题得分从正常到显著升高的各种儿童中,内化和外化行为问题与FT儿童连接额叶的白质束的平均FA呈负相关;外化行为问题与PT儿童右侧钩突的平均FA呈正相关。出生组别的不同关联表明,行为问题的神经生物学在两个出生组别中有所不同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Neuroimage. Reports
Neuroimage. Reports Neuroscience (General)
CiteScore
1.90
自引率
0.00%
发文量
0
审稿时长
87 days
期刊最新文献
Evaluating state-based network dynamics in anhedonia Unresponsiveness induced by sevoflurane and propofol is associated with reduced basal forebrain cholinergic nuclei functional connectivity in humans, a pilot exploratory study Increased functional connectivity of amygdalar-frontal pathways in patients with alcohol use disorder and childhood trauma Music literacy shapes the specialization of a right hemispheric word reading area Quantitative 3D reconstruction of viral vector distribution in rodent and ovine brain following local delivery
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1