A review on PLA-based biodegradable materials for biomedical applications

IF 5.4 1区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY GIANT Pub Date : 2024-04-04 DOI:10.1016/j.giant.2024.100261

Muzamil Hussain , Shahzad Maqsood Khan , Muhammad Shafiq , Naseem Abbas

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Abstract

Polylactic Acid (PLA) is a biodegradable polymer gaining popularity as a replacement for conventional plastics in different industrial sectors. However, PLA has inherent limitations and requires modifications to enhance its performance. This review article covers the different important aspects related to the PLA such as the synthesis route of PLA, biodegradation mechanism of PLA, properties of PLA, and applications of PLA in different sectors. The main focus of this review is to identify the different innovative copolymers, blends and composites of PLA for biomedical applications. Most important characteristics such as degradation behavior, biocompatibility and mechanical properties of these PLA-based biodegradable polymers were briefly discussed. This review indicates that the optimization of processing techniques and suitable selection of additives play an important role to achieve the desired properties of PLA. This review also discusses the issues associated to PLA-based materials for biomedical applications.

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基于聚乳酸的生物可降解材料在生物医学中的应用综述

聚乳酸（PLA）是一种可生物降解的聚合物，作为传统塑料的替代品在不同的工业领域越来越受欢迎。然而，聚乳酸有其固有的局限性，需要对其进行改性以提高其性能。这篇综述文章涵盖了与聚乳酸有关的不同重要方面，如聚乳酸的合成路线、聚乳酸的生物降解机制、聚乳酸的特性以及聚乳酸在不同领域的应用。本综述的重点是确定聚乳酸在生物医学应用中的不同创新共聚物、共混物和复合材料。简要讨论了这些基于聚乳酸的可生物降解聚合物的降解行为、生物相容性和机械性能等重要特性。综述表明，优化加工技术和适当选择添加剂对于实现聚乳酸的理想特性具有重要作用。本综述还讨论了与聚乳酸基材料的生物医学应用相关的问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

GIANT Multiple-

CiteScore

8.50

自引率

8.60%

发文量

审稿时长

42 days

期刊介绍： Giant is an interdisciplinary title focusing on fundamental and applied macromolecular science spanning all chemistry, physics, biology, and materials aspects of the field in the broadest sense. Key areas covered include macromolecular chemistry, supramolecular assembly, multiscale and multifunctional materials, organic-inorganic hybrid materials, biophysics, biomimetics and surface science. Core topics range from developments in synthesis, characterisation and assembly towards creating uniformly sized precision macromolecules with tailored properties, to the design and assembly of nanostructured materials in multiple dimensions, and further to the study of smart or living designer materials with tuneable multiscale properties.