Alternative splicing in EMT and TGF-β signaling during cancer progression

IF 12.1 1区医学 Q1 ONCOLOGY Seminars in cancer biology Pub Date : 2024-04-15 DOI:10.1016/j.semcancer.2024.04.001

Ying E. Zhang, Christina H. Stuelten

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Abstract

Epithelial to mesenchymal transition (EMT) is a physiological process during development where epithelial cells transform to acquire mesenchymal characteristics, which allows them to migrate and colonize secondary tissues. Many cellular signaling pathways and master transcriptional factors exert a myriad of controls to fine tune this vital process to meet various developmental and physiological needs. Adding to the complexity of this network are post-transcriptional and post-translational regulations. Among them, alternative splicing has been shown to play important roles to drive EMT-associated phenotypic changes, including actin cytoskeleton remodeling, cell-cell junction changes, cell motility and invasiveness. In advanced cancers, transforming growth factor-β (TGF-β) is a major inducer of EMT and is associated with tumor cell metastasis, cancer stem cell self-renewal, and drug resistance. This review aims to provide an overview of recent discoveries regarding alternative splicing events and the involvement of splicing factors in the EMT and TGF-β signaling. It will emphasize the importance of various splicing factors involved in EMT and explore their regulatory mechanisms.

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癌症进展过程中 EMT 和 TGF-β 信号传递中的替代剪接

上皮细胞向间充质细胞转化（EMT）是发育过程中的一个生理过程，在这一过程中，上皮细胞转化为间充质细胞，从而获得间充质细胞的特征，使其能够迁移并定植于次级组织。许多细胞信号通路和主转录因子对这一重要过程进行微调，以满足各种发育和生理需要。转录后和翻译后调控也增加了这一网络的复杂性。其中，替代剪接已被证明在驱动 EMT 相关表型变化（包括肌动蛋白细胞骨架重塑、细胞-细胞连接变化、细胞运动性和侵袭性）方面发挥了重要作用。在晚期癌症中，转化生长因子-β（TGF-β）是EMT的主要诱导因素，与肿瘤细胞转移、癌症干细胞自我更新和耐药性有关。本综述旨在概述有关替代剪接事件和剪接因子参与 EMT 和 TGF-β 信号转导的最新发现。它将强调参与 EMT 的各种剪接因子的重要性，并探讨其调控机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in cancer biology 医学-肿瘤学

CiteScore

26.80

自引率

4.10%

发文量

347

审稿时长

15.1 weeks

期刊介绍： Seminars in Cancer Biology (YSCBI) is a specialized review journal that focuses on the field of molecular oncology. Its primary objective is to keep scientists up-to-date with the latest developments in this field. The journal adopts a thematic approach, dedicating each issue to an important topic of interest to cancer biologists. These topics cover a range of research areas, including the underlying genetic and molecular causes of cellular transformation and cancer, as well as the molecular basis of potential therapies. To ensure the highest quality and expertise, every issue is supervised by a guest editor or editors who are internationally recognized experts in the respective field. Each issue features approximately eight to twelve authoritative invited reviews that cover various aspects of the chosen subject area. The ultimate goal of each issue of YSCBI is to offer a cohesive, easily comprehensible, and engaging overview of the selected topic. The journal strives to provide scientists with a coordinated and lively examination of the latest developments in the field of molecular oncology.