ASDAS-CRP and ASDAS-ESR cut-offs for disease activity states in axial spondyloarthritis - Are they interchangeable?

Stylianos Georgiadis, Lykke Midtbøll Ørnbjerg, Brigitte Michelsen, Tore K Kvien, Daniela Di Giuseppe, Johan K Wallman, Jakub Závada, Sella A Provan, Eirik Klami Kristianslund, Ana Maria Rodrigues, Maria José Santos, Žiga Rotar, Katja Perdan Pirkmajer, Dan Nordström, Gary J Macfarlane, Gareth T Jones, Irene van der Horst-Bruinsma, Pasoon Hellamand, Mikkel Østergaard, Merete Lund Hetland
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Abstract

Ankylosing Spondylitis Disease Activity Score with C-reactive protein (ASDAS-CRP) is recommended over erythrocyte sedimentation rate (ASDAS-ESR) to assess disease activity in axial spondyloarthritis (axSpA). Although ASDAS-CRP and ASDAS-ESR are not interchangeable, the same disease activity cut-offs are used for both. We aimed to estimate optimal ASDAS-ESR values corresponding to the established ASDAS-CRP cut-offs (1.3, 2.1 and 3.5) and investigate the potential improvement of level of agreement between ASDAS-ESR and ASDAS-CRP disease activity states when applying these estimated cut-offs.
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轴性脊柱关节炎疾病活动状态的 ASDAS-CRP 和 ASDAS-ESR 临界值--它们可以互换吗?
在评估轴性脊柱关节炎(axSpA)的疾病活动度时,推荐使用强直性脊柱炎疾病活动度评分和 C 反应蛋白(ASDAS-CRP),而不是红细胞沉降率(ASDAS-ESR)。虽然 ASDAS-CRP 和 ASDAS-ESR 不能互换,但两者使用相同的疾病活动性临界值。我们的目的是估算出与 ASDAS-CRP 既定临界值(1.3、2.1 和 3.5)相对应的最佳 ASDAS-ESR 值,并研究在应用这些估算的临界值时 ASDAS-ESR 和 ASDAS-CRP 疾病活动状态之间一致性水平的潜在改善。
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Prologue: Spondyloarthritis Unmet Research Needs Conference IV. Enhancing Equity in Clinical Research: A Multifaceted Proposal for Spondyloarthritis. Are There Disease Endotypes in Axial Spondyloarthritis and How Would We Define Them? Unmet Needs in Spondyloarthritis: Understanding and Managing Chronic Pain. Unmet Needs in Spondyloarthritis: Pathogenesis, Clinical Trial Design, and Nonpharmacologic Therapy.
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