The effect of lumbar medial branch radiofrequency neurotomy on cobb angle progression in individuals with adult scoliosis compared to natural history: A cross-sectional study

Marc Caragea , Austin Le , Tim Curtis , Amelia Ni , Tyler Clark , Andrew Joyce , Colton Hickman , Brandon Lawrence , Zane Randell , Perry Goodman , Addisyn Poduska , Michella Rasmussen , Amanda Cooper , Masaru Teramoto , Allison Glinka Przybysz , Taylor Burnham , Aaron Conger , Zachary L. McCormick
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Abstract

Background

Lumbar radiofrequency neurotomy (LRFN) effectively alleviates zygapophyseal joint-mediated pain by coagulating medial branch nerves to disrupt nociceptive signaling pathways. The concomitant denervation of multifidus fibers has led to concern that LRFN may increase segmental instability and accelerate degenerative changes in patients with certain pre-existing spinal pathologies. There is a paucity of literature evaluating whether LRFN increases the progression of spinal curvature in patients with adult scoliosis.

Objective

Compare the lumbosacral Cobb angle progression rate in patients with adult scoliosis who underwent LRFN to the annual progression rate of 0.83 ± 1.1° expected by natural history.

Design

Cross-sectional study.

Methods

Consecutive patients diagnosed with adult scoliosis who underwent LRFN to treat zygapophyseal joint-related low back pain were identified. Patient demographics, LRFN procedure details, and radiographs confirming scoliosis were collected from electronic medical records. Pre- and post-LRFN radiographs were used to calculate the average annual rate of Cobb angle progression. Data were analyzed using a Wilcoxon signed-rank test and a linear regression model.

Results

Sixty patients (mean age 69.2 ± 11.6 years; 70.0 % female) met the criteria and were included in the analyses. The mean time to radiographic follow-up was 35.0 ± 22.7 months post-LRFN. The average Cobb angle progression was 0.54 ± 3.03° per year and did not differ significantly from the known natural progression rate of 0.83 ± 1.1° per year. None of the included covariates (body mass index, LRFN laterality, and number of levels denervated) were significantly associated with the average annual Cobb angle progression rate.

Conclusions

Our results suggest that LRFN has no appreciable effect on the rate of Cobb angle progression in patients with adult scoliosis.

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腰椎内侧支射频神经切断术对成人脊柱侧凸患者科布角进展的影响与自然史的比较:横断面研究
背景腰椎射频神经切断术(LRFN)通过凝固内侧支神经来破坏痛觉信号通路,从而有效缓解颧骨关节引起的疼痛。与此同时,多裂肌纤维的去神经化使人们担心 LRFN 可能会增加节段的不稳定性,并加速已有某些脊柱病变的患者的退行性病变。评估 LRFN 是否会增加成人脊柱侧凸患者脊柱曲率进展的文献极少。方法对连续接受 LRFN 治疗颧骨关节相关腰痛的成年脊柱侧凸患者进行鉴定。研究人员从电子病历中收集了患者的人口统计学特征、LRFN手术细节以及证实脊柱侧弯的X光片。LRFN 术前和术后的 X 光片用于计算 Cobb 角的年平均进展率。结果60名患者(平均年龄69.2 ± 11.6岁;70.0%为女性)符合标准并纳入分析。LRFN术后的平均影像学随访时间为(35.0 ± 22.7)个月。Cobb 角的平均进展率为每年 0.54 ± 3.03°,与已知的每年 0.83 ± 1.1°的自然进展率没有显著差异。我们的结果表明,LRFN 对成人脊柱侧凸患者的 Cobb 角进展率没有明显影响。
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