Longitudinal determinants of employment status in people with relapsing-remitting multiple sclerosis

IF 2 Q3 NEUROSCIENCES IBRO Neuroscience Reports Pub Date : 2024-04-15 DOI:10.1016/j.ibneur.2024.04.002

E.E.A. van Egmond , K. van der Hiele , M.J. de Rooij , D.A.M. van Gorp , P.J. Jongen , J.J.L. van der Klink , M.F. Reneman , E.A.C. Beenakker , J.J.J. van Eijk , S.T.F.M. Frequin , K. de Gans , E. Hoitsma , O.H.H. Gerlach , J.P. Mostert , W.I.M. Verhagen , L.H. Visser , H.A.M. Middelkoop

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Abstract

Purpose

To investigate longitudinal relationships between employment status and disease-related, (neuro)psychological, and work-related factors in people with multiple sclerosis (MS).

Methods

170 employed people with MS underwent yearly neurological and neuropsychological examinations to assess MS-related disability and cognitive functioning. Additionally, they completed yearly questionnaires assessing depression, anxiety, fatigue, cognitive complaints, workplace support and coping. Multilevel models for change were fitted to examine progression of these factors over three years, and to assess possible relationships with change in employment status.

Results

People with a deteriorated employment status after three years reported more depression (p=0.009), a higher impact of fatigue (p<0.001), more cognitive complaints (p<0.001) and less workplace support (p=0.001) at baseline than people with a stable employment status. There were no differences in progression over time of the examined variables between people with a stable or deteriorated employment status.

Conclusion

More depression, a higher impact of fatigue, more cognitive complaints and less workplace support are predictive of a deteriorated employment status after three years in individuals with MS. How these factors progress over time is not different between those with a stable or deteriorated employment. MS-related disability, anxiety, objective cognition and coping were not related to a deterioration in employment status.

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复发缓解型多发性硬化症患者就业状况的纵向决定因素

目的研究多发性硬化症（MS）患者的就业状况与疾病相关因素、（神经）心理因素和工作相关因素之间的纵向关系。方法 170 名就业的多发性硬化症患者每年接受一次神经学和神经心理学检查，以评估与多发性硬化症相关的残疾和认知功能。此外，他们每年还填写问卷，评估抑郁、焦虑、疲劳、认知抱怨、工作场所支持和应对能力。结果与就业状况稳定的人相比，三年后就业状况恶化的人在基线时报告了更多的抑郁（p=0.009）、更高的疲劳影响（p<0.001）、更多的认知抱怨（p<0.001）和更少的工作场所支持（p=0.001）。结论更多的抑郁、更大的疲劳影响、更多的认知抱怨和更少的工作场所支持是多发性硬化症患者三年后就业状况恶化的预测因素。随着时间的推移，这些因素在就业状况稳定或恶化的患者之间并无不同。与多发性硬化症相关的残疾、焦虑、客观认知和应对能力与就业状况恶化无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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