M. E. Uspenskaya, T. A. Fedotcheva, A. N. Usenko, N. L. Shimanovsky
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引用次数: 0
Abstract
The steroid hormone 5-androstenediol (5-AED) has been advanced as a possible countermeasure for protection from ionizing radiation. It is highly effective both before and after exposure to ionizing radiation and is safe and well-tolerated. 5-AED prevents radiation-induced suppression of hematopoiesis by increasing the survival of bone-marrow cell progenitors and the numbers of circulating neutrophils and platelets. The radioprotective effectiveness of 5-AED is based on stimulation of G-CSF synthesis through NF-кB pathway activation, inhibition of pyroptosis and apoptosis, repair of radiation-induced DNAdamage, and increased expression of inducible NO-synthase genes. Development of new synthetic 5-AED derivatives helps to enhance its bioavailability and makes 5-AED a prospective molecule for creating novel safe and effective radioprotective drugs.
期刊介绍：
Pharmaceutical Chemistry Journal is a monthly publication devoted to scientific and technical research on the creation of new drugs and the improvement of manufacturing technology of drugs and intermediates. International contributors cover the entire spectrum of new drug research, including:
methods of synthesis;
results of pharmacological, toxicological, and biochemical studies;
investigation of structure - activity relationships in prediction of new compounds;
methods and technical facilities used; and
problems associated with the development of ecologically safe and economically feasible methods of industrial production.
In addition, analytical reviews of the international literature in the field provide coverage of the most recent developments around the world.
Pharmaceutical Chemistry Journal is a translation of the Russian journal Khimiko-Farmatsevticheskii Zhurnal. The Russian Volume Year is published in English from April.
All articles are peer-reviewed.
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