Acetaminophen and Thiosalicylic Acid Sensor Based on Carbon Paste Electrode Modified with Multi-Walled Carbon Nanotubes and Natural Deep Eutectic Solvent
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Abstract
A carbon paste electrode (CPE) modified with multi-walled carbon nanotubes (MWCNTs) and natural deep eutectic solvent (NADES) was prepared and applied for the simultaneous voltammetric determination of acetaminophen (ACP) and thiosalicylic acid (TSA) in real samples. Electrochemical impedance spectroscopy (EIS) was applied for investigation of electron transfer rate of [Fe(CN)6]3-/4- as a redox couple probe on the MWCNTs/NADES/CPE surface. The modified electrode preserved and combined the properties of individual modifiers synergistically. Significant enhancement in the peak current responses of ACP and TSA were observed at the modified electrode compared to the bare electrode. Under the optimal conditions, a linear dynamic range of 5–2900 μM for ACP and 5–2250 μM for TSA was obtained. The limit of detection (LOD) for ACP and TSA were 4.71 μM and 4.35 μM, respectively. Finally, this method was successfully employed for the determination of ACP and TSA in real samples.
期刊介绍：
Pharmaceutical Chemistry Journal is a monthly publication devoted to scientific and technical research on the creation of new drugs and the improvement of manufacturing technology of drugs and intermediates. International contributors cover the entire spectrum of new drug research, including:
methods of synthesis;
results of pharmacological, toxicological, and biochemical studies;
investigation of structure - activity relationships in prediction of new compounds;
methods and technical facilities used; and
problems associated with the development of ecologically safe and economically feasible methods of industrial production.
In addition, analytical reviews of the international literature in the field provide coverage of the most recent developments around the world.
Pharmaceutical Chemistry Journal is a translation of the Russian journal Khimiko-Farmatsevticheskii Zhurnal. The Russian Volume Year is published in English from April.
All articles are peer-reviewed.
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