Effectiveness of Resistance Exercise on Cognitive Function in Animal Models of Alzheimer Disease: A Systematic Review and Meta-Analysis

F. O. de Andrade Santos, A. A. Passos, Ricardo Mario Arida, L. Teixeira-Machado
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Abstract

Aim

Alzheimer’s disease (AD) is among common cause of dementia. Complementary therapies, such as resistance exercise (RE), have been proposed as an alternative for the treatment of AD. We performed a systematic review and meta-analysis to investigate the effects of RE on the cognitive function of AD animal models and their physiological mechanisms.

Methods

This review was submitted to PROSPERO (CRD42019131266) and was done according to PRISMA checklist. Four databases were used in the search: MEDLINE/PUBMED, SCOPUS, Web of Science and Google Scholar. We used SYRCLE and CAMAREDES to assess the risk of bias and methodological quality. We calculated the standardized mean difference using 95% confidence intervals and considered the random effects model and p < 0.05 to determine significance.

Key Findings

A total of 1,807 studies were founded, and after the selection process, only 11 studies were included in this review and 8 studies were included for meta-analysis. Four studies applied RE before AD induction, 7 studies applied RE after AD induction or in the AD condition. All studies included 550 adult and older animals weighing 25–280g. Our analysis revealed that RE had a positive effect on memory in AD animal models but did not show a significant impact on anxiety.

Conclusion

RE performed four or six weeks, more than three days a week, had a significant protective effect on memory. The included studies had a high risk of bias and moderate methodological quality. Therefore, RE can be a potential strategy for preventing cognitive decline in animal models.

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阻力运动对阿尔茨海默病动物模型认知功能的影响:系统回顾与元分析
目的阿尔茨海默病(AD)是导致痴呆症的常见原因之一。阻力运动(RE)等辅助疗法被认为是治疗老年痴呆症的替代疗法。我们进行了一项系统综述和荟萃分析,以研究 RE 对 AD 动物模型认知功能的影响及其生理机制。检索使用了四个数据库:MEDLINE/PUBMED、SCOPUS、Web of Science 和 Google Scholar。我们使用 SYRCLE 和 CAMAREDES 评估偏倚风险和方法学质量。我们使用 95% 的置信区间计算了标准化平均差,并考虑了随机效应模型和 p < 0.05 来确定显著性。4项研究在诱导AD之前应用RE,7项研究在诱导AD之后或在AD状态下应用RE。所有研究都纳入了 550 只体重为 25-280 克的成年和老年动物。我们的分析表明,RE 对注意力缺失症动物模型的记忆力有积极影响,但对焦虑没有显著影响。纳入的研究偏倚风险较高,方法质量中等。因此,RE 可以作为预防动物模型认知能力下降的一种潜在策略。
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来源期刊
The Journal of Prevention of Alzheimer's Disease
The Journal of Prevention of Alzheimer's Disease Medicine-Psychiatry and Mental Health
CiteScore
9.20
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期刊介绍: The JPAD Journal of Prevention of Alzheimer’Disease will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including: neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.We hope that JPAD with your contribution will play a role in the development of Alzheimer prevention.
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