Sinonasal inverted papilloma and predictors of health-related quality of life after endonasal endoscopic surgery: A prospective cohort study

IF 1.7 4区医学 Q2 OTORHINOLARYNGOLOGY Clinical Otolaryngology Pub Date : 2024-04-13 DOI:10.1111/coa.14158

Marc C. den Heijer, Gonneke E. Joustra, Karin M. Vermeulen, Astrid G. W. Korsten-Meijer, Robert A. Feijen

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Abstract

Objectives

Existing knowledge on health-related quality of life (HRQoL) after surgical removal of sinonasal inverted papilloma (IP) is limited. Moreover, predictors for a better or worse post-operative HRQoL outcome are not known. Our aim was to assess HRQoL in all three health domains (physical, psychological, and social), track its post-operative trajectory, investigate if pre-operative observations could predict distinct post-operative HRQoL outcomes, and evaluate whether physicians' interventions could contribute to improved post-operative HRQoL.

Design

Prospective cohort study.

Setting

Tertiary referral hospital.

Participants

Seventy-four patients who underwent surgery for an IP were included. They were asked to fill in the Endonasal Endoscopic Sinus and Skull-Base Surgery Questionnaire (EES-Q) pre-operatively, and then 2 weeks, 3 months, and 1 year post-operatively.

Main Outcome Measures

Linear mixed models analyses were performed to evaluate the overall post-operative HRQoL and the separate health domains, as well as the impact of specific variables (sex, age, American Society of Anaesthesiologists [ASA] classification, smoker, Krouse staging, pre-operative EES-Q score, type of surgery, and post-operative antibiotics) on HRQoL improvement.

Results

The total EES-Q score (p < .001) as well as the physical (p < .001), psychological (p = .049), and the social (p = .002) domains significantly improved post-operatively. ASA classification (p = .049), pre-operative EES-Q score (p < .001) and post-operative antibiotics (p = .036) were significant variables.

Conclusions

Overall HRQoL, as well as each of the three health domains, improved significantly. A higher ASA score, a higher pre-operative EES-Q score, and the administration of post-operative antibiotics were significant predictors for better HRQoL recovery post-operatively. Further research is necessary to confirm these results.

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鼻窦倒置乳头状瘤与鼻内镜手术后健康相关生活质量的预测因素：前瞻性队列研究

目的现有关于鼻窦倒置乳头状瘤（IP）手术切除后健康相关生活质量（HRQoL）的知识非常有限。此外，术后 HRQoL 结果好坏的预测因素尚不清楚。我们的目的是评估所有三个健康领域（身体、心理和社会）的 HRQoL，追踪其术后轨迹，研究术前观察是否能预测不同的术后 HRQoL 结果，并评估医生的干预是否有助于改善术后 HRQoL。要求他们在术前、术后2周、3个月和1年填写内窥镜鼻窦和颅底手术问卷（EES-Q）。主要结果测量进行线性混合模型分析，以评估术后总体 HRQoL 和各健康领域，以及特定变量（性别、年龄、美国麻醉医师协会 [ASA] 分级、吸烟者、Krouse 分期、术前 EES-Q 评分、手术类型和术后抗生素）对 HRQoL 改善的影响。结果 EES-Q 总分（p < .001）以及身体（p < .001）、心理（p = .049）和社会（p = .002）领域在术后均有显著改善。ASA分类（p = .049）、术前EES-Q评分（p <.001）和术后抗生素（p = .036）是重要变量。ASA评分越高、术前EES-Q评分越高以及术后使用抗生素对术后更好的HRQoL恢复具有重要的预测作用。有必要开展进一步的研究来证实这些结果。

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来源期刊

Clinical Otolaryngology 医学-耳鼻喉科学

CiteScore

4.00

自引率

4.80%

发文量

106

审稿时长

>12 weeks

期刊介绍： Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with: current otorhinolaryngological practice audiology, otology, balance, rhinology, larynx, voice and paediatric ORL head and neck oncology head and neck plastic and reconstructive surgery continuing medical education and ORL training The emphasis is on high quality new work in the clinical field and on fresh, original research. Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject. • Negative/null results In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.