Peripheral lymphocyte count as an indicator of radiotherapy effectiveness in hypopharyngeal squamous cell carcinoma

IF 1.7 4区医学 Q2 OTORHINOLARYNGOLOGY Clinical Otolaryngology Pub Date : 2024-04-10 DOI:10.1111/coa.14160

Hanqing Lin, Chunli Gao, Yu Heng, Xiaoke Zhu, Tian Wang, Liang Zhou, Ming Zhang, Chunping Wu, Lei Tao

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Abstract

Objectives

To explore the predictive significance of baseline absolute peripheral lymphocyte counts (ALC) in the effectiveness of radiation in hypopharyngeal squamous cell carcinoma (HPSCC) patients.

Design, Setting, and Participants

A retrospective study of pathologically confirmed HPSCC patients who had definitive radiation between January 2020 and January 2022 at Fudan University Eye and ENT Hospital. The routine blood results of patients were obtained to determine if the baseline ALC was connected with the response to radiation. The receiver operator characteristic (ROC) curve and LASSO-based Cox regression were employed to assess the predictive value of ALC for the efficacy of radiotherapy (RT).

Main Outcome Measures and Results

RT induced a considerable drop in ALC and the level of ALC did not revert to the baseline values 1 year after radiation. The baseline level of ALC was higher in patients who met complete response after RT. The baseline ALC and monocyte counts demonstrated the predictive value of radiation effectiveness and ALC was an independent predictor.

Conclusion

In HPSCC, lymphocytes were sensitive to radiation and reduced significantly during RT. The baseline ALC might be regarded as a predictive indicator of the effectiveness of RT.

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外周淋巴细胞计数作为下咽鳞状细胞癌放疗效果的指标

目的探讨基线外周淋巴细胞绝对计数（ALC）对下咽鳞状细胞癌（HPSCC）患者放射治疗效果的预测意义。研究人员采集了患者的血常规结果，以确定基线 ALC 是否与放疗反应相关。采用接收者操作特征曲线（ROC）和基于LASSO的Cox回归评估ALC对放疗（RT）疗效的预测价值。RT完全反应患者的ALC基线水平较高。基线 ALC 和单核细胞计数显示了放射效果的预测价值，ALC 是一个独立的预测因子。基线 ALC 可被视为 RT 疗效的预测指标。

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来源期刊

Clinical Otolaryngology 医学-耳鼻喉科学

CiteScore

4.00

自引率

4.80%

发文量

106

审稿时长

>12 weeks

期刊介绍： Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with: current otorhinolaryngological practice audiology, otology, balance, rhinology, larynx, voice and paediatric ORL head and neck oncology head and neck plastic and reconstructive surgery continuing medical education and ORL training The emphasis is on high quality new work in the clinical field and on fresh, original research. Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject. • Negative/null results In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.