Common Pathophysiological Mechanisms and Treatment of Diabetic Gastroparesis.

IF 3.3 3区 医学 Q2 CLINICAL NEUROLOGY Journal of Neurogastroenterology and Motility Pub Date : 2024-04-05 DOI:10.5056/jnm23100
Yu-Xin Zhang, Yan-Jiao Zhang, Min Li, Jia-Xing Tian, Xiao-Lin Tong
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Abstract

Diabetic gastroparesis (DGP) is a common complication of diabetes mellitus, marked by gastrointestinal motility disorder, a delayed gastric emptying present in the absence of mechanical obstruction. Clinical manifestations include postprandial fullness and epigastric discomfort, bloating, nausea, and vomiting. DGP may significantly affect the quality of life and productivity of patients. Research on the relationship between gastrointestinal dynamics and DGP has received much attention because of the increasing prevalence of DGP. Gastrointestinal motility disorders are closely related to a variety of factors including the absence and destruction of interstitial cells of Cajal, abnormalities in the neuro-endocrine system and hormone levels. Therefore, this study will review recent literature on the mechanisms of DGP and gastrointestinal motility disorders as well as the development of prokinetic treatment of gastrointestinal motility disorders in order to give future research directions and identify treatment strategies for DGP.
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糖尿病胃痉挛的常见病理生理机制和治疗方法。
糖尿病胃轻瘫(DGP)是糖尿病的一种常见并发症,主要表现为胃肠道运动障碍,即在无机械性梗阻的情况下出现胃排空延迟。临床表现包括餐后饱胀、上腹不适、腹胀、恶心和呕吐。DGP 可能会严重影响患者的生活质量和工作效率。由于 DGP 的发病率越来越高,有关胃肠动力与 DGP 之间关系的研究受到了广泛关注。胃肠动力紊乱与多种因素密切相关,包括卡贾尔间质细胞的缺失和破坏、神经内分泌系统和激素水平的异常。因此,本研究将综述有关 DGP 和胃肠道运动障碍机制的最新文献,以及胃肠道运动障碍促动力治疗的发展情况,从而给出未来的研究方向,并确定 DGP 的治疗策略。
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来源期刊
Journal of Neurogastroenterology and Motility
Journal of Neurogastroenterology and Motility GASTROENTEROLOGY & HEPATOLOGY-CLINICAL NEUROLOGY
CiteScore
6.30
自引率
8.80%
发文量
96
期刊介绍: Journal of Neurogastroenterology and Motility (J Neurogastroenterol Motil) is a joint official journal of the Korean Society of Neurogastroenterology and Motility, the Thai Neurogastroenterology and Motility Society, the Japanese Society of Neurogastroenterology and Motility, the Indian Motility and Functional Disease Association, the Chinese Society of Gastrointestinal Motility, the South East Asia Gastro-Neuro Motility Association, the Taiwan Neurogastroenterology and Motility Society and the Asian Neurogastroenterology and Motility Association, launched in January 2010 after the title change from the Korean Journal of Neurogastroenterology and Motility, published from 1994 to 2009.
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