Slope between positive and negative ERG components in patients with open-angle glaucoma

IF 2.6 4区医学 Q2 OPHTHALMOLOGY Documenta Ophthalmologica Pub Date : 2024-04-12 DOI:10.1007/s10633-024-09972-z

Maja Sustar Habjan, Barbara Cvenkel

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Abstract

Purpose

To evaluate ERG morphology, in particular the slope between P50 and N95 components of the PERG, as well as between the b-wave and the photopic negative response (PhNR) of the light-adapted (LA) ERG in patients with retinal ganglion cell (RGC) dysfunction due to open-angle glaucoma.

Methods

The PERG and LA-ERG traces of 16 glaucoma patients and 21 age-similar controls were retrospectively analysed. The ERG signal between the peak of the positive component (P50 and b-wave) towards the negative component (N95 and PhNR) was described by a linear regression y = a + bx, where the parameter b indicated the steepness of the P50-N95 and b-PhNR slope.

Results

The P50-N95 slope was less steep in glaucoma patients (−0.079 ± 0.034 vs. −0.166 ± 0.050 in controls, p < 0.001), while the b-PhNR slope was not affected (−4.2 ± 2.1 vs. −4.4 ± 1.2, p = NS). The P50-N95 slope showed strong correlation with PhNR and N95 amplitude (r = −0.68 and −0.92, respectively; p < 0.001), while the b-PhNR slope correlated only with b-wave amplitude (r = −0.66, p < 0.001).

Conclusions

The P50-N95 slope is a sensitive indicator of RGC dysfunction in patients with open-angle glaucoma. A similar component of LA-ERG, the b-PhNR slope, is less affected by glaucomatous RGC dysfunction and probably originates from similar retinal mechanisms as the b-wave.

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开角型青光眼患者ERG正负分量之间的斜率

目的评估开角型青光眼视网膜神经节细胞（RGC）功能障碍患者的ERG形态，特别是PERG的P50和N95分量之间的斜率，以及光适应（LA）ERG的b波和光敏负反应（PhNR）之间的斜率。方法回顾性分析了16名青光眼患者和21名年龄相仿的对照组患者的PERG和LA-ERG描记。用线性回归 y = a + bx 描述正分量峰值（P50 和 b 波）与负分量峰值（N95 和 PhNR）之间的 ERG 信号，其中参数 b 表示 P50-N95 和 b-PhNR 斜率的陡度。结果青光眼患者的 P50-N95 斜率较小（-0.079 ± 0.034 vs. 对照组的 -0.166 ± 0.050，p < 0.001），而 b-PhNR 斜率不受影响（-4.2 ± 2.1 vs. -4.4 ± 1.2，p = NS）。结论 P50-N95 斜率是开角型青光眼患者 RGC 功能障碍的敏感指标。LA-ERG的一个类似成分，即b-PhNR斜率，受青光眼RGC功能障碍的影响较小，可能与b波一样来自类似的视网膜机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Documenta Ophthalmologica 医学-眼科学

CiteScore

3.50

自引率

21.40%

发文量

审稿时长

>12 weeks

期刊介绍： Documenta Ophthalmologica is an official publication of the International Society for Clinical Electrophysiology of Vision. The purpose of the journal is to promote the understanding and application of clinical electrophysiology of vision. Documenta Ophthalmologica will publish reviews, research articles, technical notes, brief reports and case studies which inform the readers about basic and clinical sciences related to visual electrodiagnosis and means to improve diagnosis and clinical management of patients using visual electrophysiology. Studies may involve animals or humans. In either case appropriate care must be taken to follow the Declaration of Helsinki for human subject or appropriate humane standards of animal care (e.g., the ARVO standards on Animal Care and Use).